基于磷酸钙的多功能纳米粒子的合成及应用研究

发布时间：2019-01-16 02:01

【摘要】：随着纳米科技的进步,纳米粒子在生物医学中的应用研究逐渐成为热点,而其中复合纳米粒子可以同时复合多种纳米粒子,兼有多种功能于一体而备受关注。磷酸钙(CaP)是一种生物相容性好、无毒性的无机纳米粒子,而且人体的牙齿和骨头中就含有CaP,因此如何将CaP与其他功能性纳米粒子复合起来合成分散性好、尺寸适宜的复合纳米粒子成为当下的难题。本文提出了一种简便、可行的合成方法,以聚丙烯酸钙(PAA-Ca)为模板,与具有磁性的Fe_3O_4和碳复合,制备出分散性好的carbon/CaP/Fe_3O_4复合纳米粒子。含有Fe_3O_4的物质可用于核磁共振成像,以碳材料为基础的物质可以进行光热治疗,因此,合成的carbon/CaP/Fe_3O_4复合纳米粒子是多功能的,能够兼聚每种复合纳米粒子的特点,载药的同时有较好的磁性,光热性质以及pH/NIR双响应药物释放。进一步工作中,用同样的方法复合了CaP和Gd_2O_3:Eu,制备出了有中空介孔结构的Gd_2O_3:Eu/CaP复合纳米粒子。以Gd~(3+)为基础的物质可以用于核磁共振成像,掺杂Eu~(3+)的纳米粒子可用于荧光成像,因此制备的Gd_2O_3:Eu/CaP复合纳米粒子在生物医学中是一种非常有潜能的诊疗试剂。
[Abstract]:With the development of nanotechnology, the application of nanoparticles in biomedicine has gradually become a hot spot, and the composite nanoparticles can be combined with multiple nanoparticles, which has many functions and has attracted much attention. Calcium phosphate (CaP) is a biocompatible, nontoxic inorganic nanoparticles, and there is CaP, in human teeth and bones, so how to combine CaP with other functional nanoparticles to synthesize dispersity, Composite nanoparticles of suitable size have become a difficult problem. In this paper, a simple and feasible synthesis method was proposed. The carbon/CaP/Fe_3O_4 composite nanoparticles with good dispersion were prepared by using calcium polyacrylate (PAA-Ca) as template and magnetic Fe_3O_4 and carbon. Substances containing Fe_3O_4 can be used for nuclear magnetic resonance imaging, and carbon-based materials can be used for photothermal therapy, so synthetic carbon/CaP/Fe_3O_4 composite nanoparticles are multifunctional. It can combine the characteristics of each composite nanoparticles with good magnetic properties, photothermal properties and pH/NIR dual response drug release. In further work, Gd_2O_3:Eu/CaP composite nanoparticles with hollow mesoporous structure were prepared by combining CaP and Gd_2O_3:Eu, with the same method. Materials based on Gd~ (3) can be used in NMR imaging, and nanoparticles doped with Eu~ (3) can be used for fluorescence imaging. Therefore, the prepared Gd_2O_3:Eu/CaP nanoparticles are potential diagnostic and therapeutic reagents in biomedicine.
【学位授予单位】：东北师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TB383.1

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