近红外光控型智能纳米载药系统在肿瘤诊疗中的应用研究

发布时间：2024-02-21 06:24

　　近半个世纪以来,癌症已发展成为临床医学的重大疾病,严重威胁人类的生命健康。随着全球人口总数的不断增长、人口老龄化趋势的逐渐加剧、环境污染以及生活方式的改变,癌症的发病率和死亡率呈持续增长的态势,严重威胁人类生命安全,阻碍社会发展。肿瘤具有无限增殖、易转移和强侵润性等特点,给癌症的诊断和治疗带来了极大的困难。传统治疗癌症的手段主要有化学药物治疗、放射治疗以及手术治疗等,这些方法在一定程度上减缓并控制了肿瘤的恶化速度,但很难实现肿瘤的根除且缺乏特异性,容易对正常组织细胞造成影响,进而导致严重的毒副作用。为了提高肿瘤的治疗效果,科研人员发展了多种新兴技术,其中光疗法(主要包括光热疗法和光动力学疗法)作为一种新型的抗肿瘤手段,因其具有良好的组织穿透性和较小的毒副作用,受到越来越多的关注。光热治疗(Photothermal therapy,PTT)是一种新型的微创肿瘤治疗手段,使用该方法进行治疗时,光热转化剂能够将近红外光的能量转化为热能,使肿瘤或癌变组织温度上升至有效治疗温度范围内,并利用肿瘤组织和正常组织温度耐受力的差异,在不损伤正常组织的前提下,达到杀灭肿瘤细胞的目的。在光热治疗中,我们还...

【文章页数】：111 页

【学位级别】：硕士

【文章目录】：
中文摘要
ABSTRACT
Chapter1 Introduction
    1.1 Photothmal therapy
        1.1.1 Introduction of the photothermal therapy
        1.1.2 Common photothermal agents
    1.2 Photodynamic therapy
        1.2.1 Introduction of photodynamic therapy
        1.2.2 The mechanism of photodynamic therapy
        1.2.3 The photosensitizers of photodynamic therapy
        1.2.4 The functional nanomaterials of photodynamic therapy
    1.3 Different model imaging technologies of cancer therapy
        1.3.1 Conventional single-modality imaging
        1.3.2 Multi-modality imaging
    1.4 Project design
Chapter2 TD-controlled and ICG-loaded CuS@mSiO₂ for fluorescence/PA dual-imaging guided synergistic PTT/PDT cancer therapy
    2.1 Brief introduction
    2.2 Materials and methods
        2.2.1 Experimentalmaterials and equipments
        2.2.2 Preparation and characterization of CuS@mSiO2

        2.2.3 Preparation and characterization of CuS@mSiO₂-TD/ICG
        2.2.4 Cell culture and cellular studies
        2.2.5 In vivo animal experiments
    2.3 Results and discussion
        2.3.1 Preparation and characterization of CuS@mSiO₂

        2.3.2 Drug loadingand characterization of CuS@mSiO₂-TD/ICG
        2.3.3 Cellular studies
        2.3.4 In vivo animal studies
    2.4 Brief summary
Chapter3 BSA-bioinspired gadolinium hybrid-functionalized hollow gold nanoshells for fluorescence/PA/CT/MR quad-modal imaging guided PTT/PDT cancer therapy
    3.1 Brief introduction
    3.2 Materials and methods
        3.2.1 Experimentalmaterials and equipments
        3.2.2 Preparation and characterization of Au@BSA-Gd
        3.2.3 ICG loading and characterization of ICG-Au@BSA-Gd
        3.2.4 Cell culture and cellular studies
        3.2.5 In vivo animal experiments
    3.3 Results and discussion
        3.3.1 Preparation and Characterization of HAuNs
        3.3.2 Preparation and Characterizationof Au@BSA-Gd
        3.3.3 Preparation and Characterizationof ICG-Au@BSA-Gd
        3.3.4 Cell culture and cellular studies
        3.3.5 In vivo animal studies
    3.4 Brief summary
Chapter4 Conclusion and prospect
    4.1 Conclusion
    4.2 Prospect
References
Notes on publications and participation in scientific research
Acknowledgement



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