具有双重治疗机制的磁性纳米无定型氧化铁基药物递送系统（英文）
发布时间：2024-12-18 00:49
合成一种具有pH响应性的聚乙二醇（PEG）修饰无定形介孔氧化铁纳米粒子（AFe-PEG）.这种纳米粒子可以高效负载药物分子如阿霉素（DOX）,构成新型多功能AFe-PEG/DOX药物递送体系.DOX的负载率高达948 mg/g-纳米粒子.在酸性溶液中,AFePEG/DOX纳米粒子不仅可以有效释放DOX,同时可以释放Fe离子进行Fenton反应,将H2 O2转变成·OH自由基.体外实验结果表明,AFe-PEG/DOX纳米粒子对HeLa细胞同时具有化疗和化学动力学疗法的疗效.同时,由于AFe-PEG/DOX纳米粒子本身的磁性,使其在外部磁场中的细胞内化效率也得到了提高.
【文章页数】：14 页
【文章目录】：
I.INTRODUCTION
II.MATERIALS AND METHODS
III.RESULTS AND DISCUSSION
IV.CONCLUSION
Supporting Information
Part I.Synthesis and characterization of compounds employed in this work.
Part II.Working curve of DOX
Part III.Characterization of nanoparticles
Part IV.Thermo-gravimetric analysis(TGA)of nanoparticles
Part V.The Fluorescence images of Hela cells.
Part VI.The cellular internalization and intracellular trafficking of DOX
REFERENCES
本文编号：4016787
【文章页数】：14 页
【文章目录】：
I.INTRODUCTION
II.MATERIALS AND METHODS
III.RESULTS AND DISCUSSION
IV.CONCLUSION
Supporting Information
Part I.Synthesis and characterization of compounds employed in this work.
Part II.Working curve of DOX
Part III.Characterization of nanoparticles
Part IV.Thermo-gravimetric analysis(TGA)of nanoparticles
Part V.The Fluorescence images of Hela cells.
Part VI.The cellular internalization and intracellular trafficking of DOX
REFERENCES
本文编号：4016787
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