刚性微球微流控惯性聚焦过程研究

发布时间：2018-04-16 23:17

本文选题：微流控 + 惯性聚焦流　；参考：《工程热物理学报》2017年08期

【摘要】：利用流体的惯性效应实现刚性微球的高通量精确操控是一种新颖微流控方法,其在材料合成、生化反应和医学诊断等领域有着重要应用。本研究为实现刚性微球的等间距聚焦流动,设计制备了基于惯性聚焦的具有多个聚焦单元和鞘液聚焦结构的微流控芯片,实验以直径10μm的聚苯乙烯微球作为模型,考察了在特定微流条件下微球的聚焦效果。结果表明,在乙醇样品液以710μL/min流量均匀流动时,微球自第60个聚焦单元开始聚焦形成单一排列的流型。在已稳定聚焦成单一排列的微球队列上叠加相应条件的鞘液聚焦流,能够增强流动聚焦效果,并可控制微球间的相对距离。上述结果为深入研究微流体环境下刚性粒子的运动特性和开发相关的微流芯片提供了重要参考。
[Abstract]:It is a novel microfluidic control method to use the inertial effect of fluid to realize the high-throughput precise manipulation of rigid microspheres, which has important applications in the fields of material synthesis, biochemical reaction and medical diagnosis.In order to realize the equal-spacing focusing flow of rigid microspheres, a microfluidic chip with multiple focusing units and sheath fluid focusing structure based on inertial focusing was designed and fabricated. The experimental model was polystyrene microspheres with a diameter of 10 渭 m.The focusing effect of microspheres under specific microflow conditions was investigated.The results show that when the flow rate of ethanol sample is 710 渭 L/min, the microspheres begin to focus from the 60th focus unit to form a single flow pattern.When the scabbard fluid focusing flow is superimposed on the queue of microspheres which have been stably focused into a single arrangement, the flow focusing effect can be enhanced and the relative distance between the microspheres can be controlled.These results provide an important reference for the further study of the motion characteristics of rigid particles in microfluid environment and the development of microfluidic chips.
【作者单位】：广东工业大学材料与能源学院广东省功能软凝聚态物质重点实验室;
【基金】：国家自然科学基金资助项目(No.51606046) 广州市对外科技合作项目(No.2016201604030063)
【分类号】：TN492

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