无创血糖近浮动基准参考测量方法的仿体实验验证

发布时间：2018-05-08 20:23

  本文选题：无创血糖检测 + 漫反射光　； 参考：《光谱学与光谱分析》2017年06期

【摘要】：在近红外无创血糖测量中,由葡萄糖引起的信号变化十分微弱,极易受到人体背景、测量仪器、周围环境等变化的影响,限制了无创血糖检测的精度。针对这个问题,提出应用浮动基准位置理论进行背景变异的校正。但是由于个体的差异性与人体环境的复杂多变性,浮动基准位置会因人而异。通过对人体手掌三层皮肤模型进行蒙特卡洛模拟,发现其在1 000~1 700nm近红外波段的浮动基准位置基本处于距光源径向距离2mm附近。为了提高浮动基准位置理论在不同人体之间的适用性,提出了一种近浮动基准参考测量方法,即以径向距离2mm处作为参考位置进行背景干扰的修正,并通过仿体实验验证其效果。选取与人体手掌皮肤模型的浮动基准位置较为接近的2%和3%浓度的Intralipid仿体溶液进行实验。实验结果表明近浮动基准修正法可以消减光源漂移对测量结果的影响,提高数据的重复性和稳定性;同时通过对不同葡萄糖含量的2%和3%浓度的Intralipid溶液进行多次漫反射信号采集并建立葡萄糖浓度预测模型,发现修正后的回归模型的预测均方根误差(RMSEP)分别降低了38.51%~79.98%和29.72%~52.22%,说明该方法能够比较有效地消除两个测量位置处共同的背景干扰,提高校正模型的预测精度。仿体实验验证的结果,为下一步近浮动基准参考测量方法的在体测量提供了有力的支撑。
[Abstract]:In the near infrared noninvasive blood glucose measurement, the signal caused by glucose is very weak, which is easily affected by the changes of human background, measuring instruments and surrounding environment, which limits the accuracy of noninvasive blood glucose detection. In order to solve this problem, the theory of floating datum position is proposed to correct the background variation. However, due to the diversity of individuals and the complex variability of human environment, the position of floating datum varies from person to person. By Monte Carlo simulation of a three-layer skin model of the human palm, it is found that the floating reference position in the near infrared band of 1 000 700nm is basically near the radial distance from the light source 2mm. In order to improve the applicability of the theory of floating reference position between different human bodies, a near floating reference measurement method is proposed, in which the radial distance 2mm is used as the reference position to correct the background interference. The effect was verified by body-imitating experiment. The experiments were carried out with 2% and 3% concentrations of Intralipid mimic solution, which was close to the floating datum position of the human palm skin model. The experimental results show that the near floating datum correction method can reduce the influence of light source drift on the measurement results and improve the repeatability and stability of the data. At the same time, the Intralipid solution with 2% and 3% glucose content was collected by multiple diffuse reflectance signals and the prediction model of glucose concentration was established. It is found that the RMS EPs of the modified regression model are reduced by 38.51% and 29.722%, respectively, indicating that this method can effectively eliminate the common background interference at the two measuring positions and improve the prediction accuracy of the correction model. The results of simulation experiment provide a strong support for the in vivo measurement of near floating reference measurement method.
【作者单位】： 天津大学精密测试技术及仪器国家重点实验室;天津市生物医学检测技术及仪器重点实验室天津大学;
【基金】：国家自然科学基金项目(81401454,81471698) “111”计划(B07014) 中国博士后科学基金项目(2013M541174)资助
【分类号】：O434.33;R446.1
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本文编号：1862937