基于光声光谱联合主成分回归法的血糖浓度无损检测研究

发布时间：2018-01-12 20:20

本文关键词：基于光声光谱联合主成分回归法的血糖浓度无损检测研究　出处：《光谱学与光谱分析》2016年06期 　论文类型：期刊论文

【摘要】：利用可调谐脉冲激光器激发联合聚焦超声探测器前向探测模式搭建了一套血糖光声无损检测实验装置。为了测试该装置的可靠性,实验中利用532nm泵浦Nd∶YAG调Q脉冲激光器激发不同浓度的葡萄糖水溶液产生实时光声信号;采用脉冲激光在近红外波段1 300~2 300nm内固定间隔波长10nm扫描方式激发不同浓度的葡萄糖水溶液,获取了不同波长下的葡萄糖光声峰峰值,利用差谱方法筛选出了多个葡萄糖的特性波长;然后采用主成分回归算法优选了三个特性波长,并建立了浓度梯度与对应三个优选波长光声峰峰值之间的数学校正模型。实验表明,葡萄糖水溶液的光声信号符合弱吸收介质的柱状光声源模型;利用建立的校正模型对校正集和预测集的葡萄糖浓度预测结果表明,葡萄糖浓度的校正和预测均方根误差均小于10mg·dl~(-1),相似系数为0.993 6。
[Abstract]:In order to test the reliability of a tunable pulse laser excited combined focused ultrasonic detector, a set of photoacoustic nondestructive testing device for blood sugar was built. In the experiment, a 532nm pumped Nd:YAG Q-switched pulse laser is used to excite different concentrations of glucose aqueous solution to produce real-time photoacoustic signals. Different concentrations of glucose aqueous solution were excited by pulsed laser scanning at a fixed wavelength of 10 nm in the near infrared band of 1 300 ~ 2 300 nm. The peak value of glucose photoacoustic peak at different wavelengths was obtained, and the characteristic wavelengths of multiple glucose were screened by differential spectrum method. Then the principal component regression algorithm is used to select three characteristic wavelengths, and a mathematical correction model between the concentration gradient and the corresponding peak value of photoacoustic peaks of the three selected wavelengths is established. The photoacoustic signal of glucose aqueous solution accords with the columnar photoacoustic source model of weak absorption medium. Using the established calibration model to predict the glucose concentration of the correction set and the prediction set, the results show that the root mean square error of the correction and prediction of glucose concentration is less than 10mg 路dl-1). The similarity coefficient is 0.993 6.
【作者单位】：江西科技师范大学光电子与通信重点实验室;南昌大学机电工程学院;
【基金】：国家自然科学基金项目(61068002) 江西省自然科学基金项目(20151BAB202011) 江西省科技支撑计划基金项目(20132BBG70103) 江西科技师范大学校级创新团队基金项目(2013CXTD001) 校级青年拔尖人才自然科学基金项目(2014QNBJRC004)资助
【分类号】：O657.3;R446.11
【正文快照】： 引言糖尿病已经成为继心脑血管疾病和恶性肿瘤之后,危及人类生存质量的第三大杀手。目前医学还不能彻底根治糖尿病,主要是通过频繁地监测血糖浓度来调整口服降糖药物和胰岛素的用量,从而控制血糖值。因此有效地监测患者的血糖浓度已成为糖尿病诊断和治疗的关键。常规检测是通

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