谷氨酸赖氨酸无规共聚物和谷氨酸精氨酸无规共聚物的合成及性能

发布时间：2018-02-28 01:31

本文关键词： 开环聚合无规共聚物 pH敏感　出处：《高等学校化学学报》2017年01期 　论文类型：期刊论文

【摘要】：采用氨基酸-N-内羧酸酐(氨基酸-NCA)开环聚合的方法,并通过改变开环聚合时谷氨酸-N-内羧酸酐(BLG-NCA)与赖氨酸-N-内羧酸酐[Lys(Z)-NCA]的投料比以及BLG-NCA与鸟氨酸-N-内羧酸酐[Orn(Z)-NCA]的投料比,经过脱保护和胍基化反应得到一系列谷氨酸赖氨酸无规共聚物Poly(E,K)和谷氨酸精氨酸无规共聚物Poly(E,R).核磁共振氢谱(~1H NMR)和核磁共振定量碳谱(13C NMR)分析结果表明,合成了无规共聚物Poly(E,K)和Poly(E,R),且二者中不同氨基酸的摩尔比接近开环聚合时相应NCA的投料比.动态光散射(DLS)测定结果表明,无规共聚物在pH=7.4的正常生理环境中形成的胶束粒径均一、尺寸小于200 nm.Zeta电位表征结果表明,无规共聚物Poly(E,K)和Poly(E,R)的Zeta电位值随着溶液pH值的变化而变化,具有pH敏感性.
[Abstract]:The method of ring-opening polymerization of amino acid -NCA-NCA was adopted, and the ratio of glutamic acid-N-endocarboxylic anhydride (BLG-NCA) to lysine-N- endocarboxylic anhydride [Lys(Z)-NCA] and the ratio of BLG-NCA to Orn(Z)-NCA during ring-opening polymerization were changed. A series of random copolymers of glutamate lysine (Poly (EK)) and arginine (Glutamic acid) were obtained by deprotection and guanidine group reaction. The results of 1H NMR and 13C-NMRs showed that a series of random copolymers of glutamate lysine and arginine were obtained. The random copolymers (Poly (EK)) and Poly (Amino) (RX) were synthesized, and the molar ratio of different amino acids was close to that of the corresponding NCA in the ring-opening polymerization. The results of dynamic light scattering (DLS) showed that the micelle size of the random copolymers formed in the normal physiological environment of pH=7.4 was uniform. The results of characterization of the size less than 200 nm.Zeta potential show that the Zeta potential values of the random copolymers Polyacrylum Euclidene (K) and Poly (EJ) R) vary with the change of pH value of the solution and are pH sensitive.
【作者单位】：湘潭大学化学学院环境友好化学与应用教育部重点实验室;中国科学院长春应用化学研究所生态环境高分子材料重点实验室;
【基金】：国家自然科学基金(批准号:51373168)资助~~
【分类号】：O631

【相似文献】