金催化肌酸酐与靛红的加成反应:一种可持续的绿色方法用于非对映选择合成3-取代的3-羟基靛红（英文）

发布时间：2018-03-05 22:24

本文选题：肌酸酐　切入点：金催化　出处：《催化学报》2017年05期 　论文类型：期刊论文

【摘要】：报道了水介质中金催化肌酸酐与不同靛红之间的醛醇缩合反应.该法无需繁杂的溶剂萃取和柱色谱技术,只需简单的过滤即可将产物分离出来,因而操作简单.通过较宽范围的靛红衍生物的反应,均可高产率并完全地制取相应的顺式醛醇缩合产物,因此该法表现出较高的通用性.还将该合成策略进一步拓展至靛红,肌酸酐和丙二腈的串联反应,可高产率、完全的制取反式多组分产物.采用分光光度法测定了合成产物的抗氧化性能,结果表明,与标准物相比,含有卤素原子的三个化合物(2c,2d和2e)表现出最高的活性.
[Abstract]:The aldehydes and alcohols condensation between creatinine and different indirubin catalyzed by gold in aqueous medium are reported. The product can be separated by simple filtration without complicated solvent extraction and column chromatography. The reaction of indirubin derivatives in a wide range can yield high yield and completely produce the corresponding cis-aldehydes condensation products. Therefore, the method has a high versatility, and the synthesis strategy is further extended to indirubin. The series reaction of creatinine and malonitrile can produce the trans multicomponent product in high yield. The oxidation resistance of the synthesized product was determined by spectrophotometry. Three compounds containing halogen atoms, 2 d and 2 e, exhibited the highest activity.
【作者单位】：悉达中央研究委员会
【基金】：the Central Council for Research in Siddha (CCRS),India the management of Inogent Laboratories Ltd.,India the Science and Engineering Research Board (SERB) for the financial support (SERB/F/5666/2015-16)
【分类号】：O621.251

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