高选择性的有机合成新反应与新策略研究进展

发布时间：2018-03-10 12:30

本文选题：不对称催化　切入点：手性配体　出处：《中国科学基金》2017年06期 　论文类型：期刊论文

【摘要】：本文基于"高选择性的有机合成新反应与新策略"国家自然科学基金创新研究群体部分研究成果,系统综述了在不对称催化合成新催化剂和新机制、有机合成新试剂及天然产物全合成等方面的研究进展。本研究群体发展了具有自主知识产权的新型"优势"手性双氮氧酰胺—金属配合物催化剂和新型开链胍类催化剂,在新反应和有重要用途的手性化合物的高选择性合成方面取得了优秀的结果;发展了手性有机胺类小分子的三烯胺催化新模式,实现了远程手性控制。基于串联反应策略、仿生策略及汇聚合成策略等,完成了多个复杂结构和重要活性天然产物的高效全合成,发展了一些有重要用途的药物分子的合成新途径。
[Abstract]:Based on the research results of "New reactions and Strategies for highly selective Organic Synthesis", a systematic review of new catalysts and mechanisms for asymmetric catalytic synthesis has been made by the National Natural Science Foundation of China. This research group has developed a new "dominant" chiral diazoxamide metal complex catalyst and a new open-chain guanidine catalyst with independent intellectual property rights. Excellent results have been obtained in the new reactions and the highly selective synthesis of chiral compounds with important applications. A new model of trienamine catalysis for small chiral organic amines has been developed to achieve remote chiral control. Biomimetic strategies and aggregation synthesis strategies have been used to complete the highly efficient synthesis of many complex structures and important active natural products, and some new approaches to the synthesis of some important drug molecules have been developed.
【作者单位】：四川大学化学学院;四川大学华西药学院;
【基金】：国家自然科学基金创新研究群体项目“高选择性的有机合成新反应和新策略”(项目批准号:21021001)、第一次延续资助(项目批准号:21321061)的连续支持
【分类号】：O621.3

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