拉西地平的太赫兹光谱实验研究

发布时间：2018-03-12 20:50

  本文选题：太赫兹光谱　切入点：拉西地平　出处：《光谱学与光谱分析》2017年08期 　论文类型：期刊论文

【摘要】：测量了高纯拉西地平(98%)和拉西地平口服药片(2%)0.5~1.8THz的太赫兹反射时域信号,并分别提取出二者的吸收谱和折射率谱。通过将纯样品的吸收峰位与CASTEP晶体软件计算得到的吸收线位置进行比较,并用Lorentz线型函数对其中位置相近的吸收峰进行拟合,得到了拉西地平的指纹谱,并从实验上确定了拉西地平的六个特征频率,这些频率分别为0.62,0.78,1.07,1.28,1.63和1.76THz;由于口服药片中添加了其他大分子物质作为辅料,这些物质带来的吸收本底会对拉西地平的特征峰的识别造成干扰,因此,特征吸收峰数量减少至四个,它们分别是0.62,0.78,1.28和1.63THz;另外,纯样品和口服药片的折射率谱存在较大差异,这也与口服药中添加的辅料有关。尽管实际的拉西地平口服药片中含有的拉西地平的成分很低,但是,太赫兹指纹谱依然可以将拉西地平的特征频率识别出来。因此,太赫兹时域光谱技术对拉西地平药品的成分检测是十分有效的。
[Abstract]:The time domain signals of terahertz reflex of high purity lacidipine 98) and lacidipine oral tablets were measured at 0.5 THz and 1.8 THz. The absorption spectra and refractive index spectra were extracted respectively. The position of absorption peak of pure sample was compared with the position of absorption line calculated by CASTEP crystal software, and the absorption peak with close position was fitted by Lorentz linear function. The fingerprint spectra of lacidipine were obtained, and the six characteristic frequencies of lacidipine were determined experimentally. These frequencies were 0.62kW 0.781.071.281.63 and 1.76THz. because other macromolecular substances were added to the oral tablets as excipients, The absorption background brought by these substances interferes with the recognition of characteristic peaks of lacidipine, so the number of characteristic absorption peaks is reduced to four, which are 0.62o0.78h1.28 and 1.63THz. in addition, there are significant differences in refractive index spectra between pure samples and oral tablets. This is also related to the addition of excipients to oral drugs. Although the actual lacidipine tablets contain very low levels of lacidipine, the terahertz fingerprint can still identify the characteristic frequencies of lacidipine. Terahertz time-domain spectroscopy is very effective for the detection of lacidipine.
【作者单位】： 北京市应用光学重点实验室北京师范大学物理系;太赫兹光电子教育部重点实验室首都师范大学物理系;
【基金】：国家自然科学基金项目(61371055) 北京市大学生科学研究与创业行动计划项目资助
【分类号】：O657.3;TQ460.72
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