金、银纳米颗粒溶胶对三种瘦肉精分子拉曼表面信号增强效果及性质比较研究

发布时间：2018-03-13 01:17

本文选题：表面增强拉曼光谱　切入点：纳米颗粒　出处：《现代食品科技》2016年01期 　论文类型：期刊论文

【摘要】：采用柠檬酸钠还原法制备了银溶胶以及三种不同粒径大小的金溶胶作为拉曼表面增强剂,通过紫外-可见吸收光谱及透射电镜(TEM)比较其尺寸、粒度、分散性及稳定性,后选取盐酸氯丙那林、硫酸特布他林和盐酸班布特罗三种β受体激动剂类药物作为检测对象,观察拉曼信号增强效果。结果表明,金、银溶胶对β受体分子的表面增强拉曼信号增强信号基本上没有干扰。金溶胶的纳米粒子大小对于吸附能力有一定程度的影响,其颗粒大小更易于通过加入柠檬酸钠的方式进行调节,而银纳米溶胶颗粒粒径较不易控制。金溶胶能较长时间保持稳定,而银溶胶较易发生沉淀,但银纳米颗粒与目标分子结合后能产生更为强烈的共振现象,与金溶胶相比具有更强的表面增强活性,在拉曼信号增强目标分子时效果更好。
[Abstract]:Silver sol and three kinds of gold sol with different particle sizes were prepared by sodium citrate reduction method as Raman surface intensifiers. The size, particle size, dispersion and stability of silver sol were compared by UV-Vis absorption spectra and transmission electron microscopy (TEM). Three 尾 -receptor agonists, clopramine hydrochloride, terbutaline sulfate and bambuterol hydrochloride, were selected to observe the enhancement of Raman signal. Silver sol has no interference with the enhanced Raman signal of 尾 -receptor molecule, and the size of gold sol has a certain influence on the adsorption ability. The particle size is easier to be adjusted by adding sodium citrate, while the particle size of silver nanoparticles is more difficult to control. The gold sol can be kept stable for a long time, while the silver sol is more prone to precipitate. However, silver nanoparticles can produce stronger resonance phenomenon when combined with the target molecule, and have stronger surface enhancement activity than gold sol, and the effect is better when the Raman signal is used to enhance the target molecule.
【作者单位】：广西壮族自治区食品药品检验所;中华全国供销合作总社济南果品研究院;河北联合大学基础医学院药理教研室;
【基金】：中国食品药品检定研究院“中青年发展研究基金”项目(2013WC3) “广西自然科学青年基金”项目(2014GXNSFBA118059)
【分类号】：O657.37

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