聚乳酸微胶囊的层层自组装及表征

发布时间：2018-03-18 19:50

本文选题：微胶囊　切入点：层层自组装　出处：《高分子材料科学与工程》2017年08期 　论文类型：期刊论文

【摘要】：以碳酸钠和氯化钙为原料制备的碳酸钙微球为模板,采用层层自组装的方法,将左旋聚乳酸(PLLA)和右旋聚乳酸(PDLA)逐层组装在碳酸钙微球上,然后用乙二胺四乙酸二钠(EDTA)去除模板碳酸钙后成功制备了聚乳酸中空微胶囊,并采用扫描电镜、原子力显微镜、透射电子显微镜、激光共聚焦显微镜、差示扫描量热仪和广角X射线衍射仪对微胶囊进行初步表征。结果表明,微胶囊层形成的层间驱动力为聚乳酸异构体之间的立构复合作用,微胶囊呈现经典的褶皱状,囊壁厚度约为90~100nm,内部为空腔结构,囊壁允许小分子物质透过,在载药缓释领域具有很好的应用前景。
[Abstract]:Calcium carbonate microspheres, prepared from sodium carbonate and calcium chloride, were assembled layer by layer on calcium carbonate microspheres by layer-by-layer self-assembly method. Polylactic acid hollow microcapsules were successfully prepared by removing template calcium carbonate with EDTA-EDTA. Scanning electron microscope, atomic force microscope, transmission electron microscope, laser confocal microscope were used to prepare polylactic acid hollow microcapsules. Differential scanning calorimetry (DSC) and wide-angle X-ray diffractometer (WAXD) were used to characterize microcapsules. The results showed that the interlaminar driving force of microencapsulation was the combination of polylactic acid isomers, and the microcapsules showed classic folds. The thickness of the capsule wall is about 90 ~ 100 nm, and the internal cavity structure is hollow. The wall of the capsule allows small molecules to permeate, so it has a good application prospect in the field of drug delivery sustained release.
【作者单位】：纤维材料改性国家重点实验室东华大学材料科学与工程学院;
【分类号】：O633.14

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