单波长光声光谱血氧饱和度检测技术研究（英文）

发布时间：2018-04-03 23:42

本文选题：光声图像　切入点：单波长　出处：《光谱学与光谱分析》2017年08期

【摘要】：血氧饱和度(SO_2)为临床观察病情变化提供了有意义的指标。传统血氧饱和度检测研究工作多采用双光源和多光源光电容积脉搏波描记法实现无创检测来减少病人痛苦。通过研究生物组织对光的吸收和散射特性,将光谱学和光声技术相结合提出了一种无创式单光源检测血氧饱和度(SO_2)、脱氧血红蛋白浓度[HBR]和氧合血红蛋白浓度[HbO_2]的新方法。该方法基于血液对光信号的吸收和散射理论基础和光声信号呈现吸收线形关系建立单波长光声光谱血氧饱和度检测技术,不仅可以进行指标性参数分析还可以对组织成像。为了验证该技术可行性,在实验中采用单波长激光脉冲光源,以绿色和红色墨水的混合液体作为含有脱氧血红蛋白和氧合血红蛋白的血液模型注入软管模拟人体血液环境。其中红色墨水的含量类比于血液中含氧血红蛋白含量,从而可通过测量计算出红色和绿色墨水浓度来表征伪血氧饱和度(poseudo-SO_2)。实验结果表明,所测的伪血氧饱和度与实际浓度误差不超过6.97%,采用该方法量化血氧饱和度是可行的;同时利用实验结果,结合光声成像技术完成了对伪血液中单圆管截面成像。该方法替代多波长光谱分析的方法能显著降低激光系统和便携式实现成本。
[Abstract]:Blood oxygen saturation (so _ 2) provides a significant index for clinical observation of the state of illness.In order to reduce the pain of patients, the traditional research work of oxygen saturation measurement mostly uses double light source and multiple light source photoelectric volumetric pulse wave method to realize noninvasive detection.By studying the light absorption and scattering characteristics of biological tissues, a new method for the detection of blood oxygen saturation, deoxyhemoglobin concentration (HBR) and oxygenated hemoglobin concentration (HbO_2) by combining spectroscopy with photoacoustic technique is proposed.Based on the theory of blood absorption and scattering and the absorption linear relationship of the photoacoustic signal, a single wavelength photoacoustic spectral oxygen saturation detection technique is established, which can not only be used for parameter analysis, but also for tissue imaging.In order to verify the feasibility of this technique, a single wavelength laser pulse light source was used in the experiment. The mixture of green and red ink was used as a blood model containing deoxyhemoglobin and oxygenated hemoglobin to simulate the human blood environment.The content of red ink is analogous to the content of oxygenated hemoglobin in blood, so the pseudo oxygen saturation can be expressed by measuring and calculating the concentration of red ink and green ink.The experimental results show that the error between the measured pseudo oxygen saturation and the actual concentration is less than 6.97, and it is feasible to quantify the oxygen saturation by using this method, and at the same time, using the experimental results and the photoacoustic imaging technique, we have completed the imaging of the cross section of the single tube in the pseudo blood.This method can significantly reduce the cost of laser system and portable implementation instead of multiwavelength spectral analysis.
【作者单位】：四川大学物理科学与技术学院;
【基金】：Project Supported by National Natural Science Foundation of China(81370350) Project Supported by Sichuan Provincial Department of Science and Technology(2012JY0089)
【分类号】：O657.3;R44

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