温敏性聚合物Janus纳米片的制备及性质研究

发布时间：2018-04-15 03:26

本文选题：Janus纳米片 + 温度响应性　；参考：《辽宁大学》2016年硕士论文

【摘要】：Janus结构材料有着其独特的组成与结构,有着诸多吸引人的性质,在很多方面有着普遍的应用。科学家们在其结构与组成方面做了大量的研究,制备了各种各样形貌的Janus结构材料。各向异性的柔性Janus纳米片本身易折叠,具有更加丰富的聚集行为。本文制备了一种温敏性聚合物Janus纳米片PNVCL/cPCL,并研究了其对于DOX的封装及释放,具体工作如下：1、以纳米Si02微球为硬模板,在硅球表面锚固偶氮类引发剂ACPA,得到SNP-ACPA;以SNP-ACPA为引发剂,巯基乙醇为链转移剂,引发N-乙烯基己内酰胺聚合,获得端羟基聚N-乙烯基己内酰胺接枝的纳米Si02微球(SNP-g-PNVCL-OH);以SNP-g-PNVCL-OH为引发剂,辛酸亚锡为催化剂,以Bis (ε-caprolactone-4-yl) (BCY)为交联剂,以ε-己内酯为单体,合成外层交联的聚合物包覆的纳米二氧化硅微球(SNPs-g-PNVCL-b-cPCL),用氢氟酸将得到的聚合物包覆的硅球刻蚀,用细胞粉碎机在低温下进行粉碎,得到聚合物Janus片。2、研究了不同温度下,纳米片在水中的分散程度。利用紫外-可见分光光度计测定了Janus内米片的载药量和载药率,以及在不同温度下,体外释放情况。温度高于PNVCL的LCST时,Janus片PNVCL一侧由亲水变为疏水,在水中的自组装被破坏,更有利于药物的释放,对于肿瘤细胞靶向释放有着潜在的应用价值。
[Abstract]:Janus structural material has its unique composition and structure, has many attractive properties, and has been widely used in many aspects.Scientists have done a lot of research on their structure and composition, and have prepared various morphologies of Janus structural materials.The anisotropic flexible Janus nanoparticles are easy to fold and exhibit richer aggregation behavior.In this paper, we have prepared a kind of thermo-sensitive polymer Janus nanochip PNVCLR / cPCL, and studied its encapsulation and release to DOX. The specific work is as follows: 1. Using nanometer-sized Si02 microspheres as hard template to anchor azo initiator ACPA on the surface of silica ball, SNP-ACPA was obtained. SNP-ACPA was used as initiator.Mercaptoethanol was used as the chain transfer agent to initiate the polymerization of N-vinylcaprolactam, and the hydroxy-terminated poly (N-vinylcaprolactam) grafted nano-scale Si02 microspheres SNP-g-PNVCL-OHN were obtained, and Bis (蔚 -caprolactone-4-ylBCY) was used as the crosslinking agent with SNP-g-PNVCL-OH as the initiator and stannous octanoate as the catalyst.Using 蔚 -caprolactone as monomer, the polymer coated nano-silica microspheres SNPs-g-PNVCL-b-cPCLL were synthesized. The polymer-coated silica spheres were etched with hydrofluoric acid, and then comminuted by cell crusher at low temperature.Polymer Janus sheet. 2 was obtained. The dispersion degree of nanoparticles in water was studied at different temperatures.UV-Vis spectrophotometer was used to determine the drug loading and drug loading rate of Janus tablets and its release in vitro at different temperatures.When the temperature of LCST is higher than that of PNVCL, the PNVCL side of PNVCL film changes from hydrophilic to hydrophobic, and the self-assembly in water is destroyed, which is more favorable for the release of drugs, and has potential application value for the targeted release of tumor cells.
【学位授予单位】：辽宁大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：O631;TQ460.1

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