金属配位壳聚糖凝胶及复合膜的制备与研究

发布时间：2018-04-22 12:27

  本文选题：金属配位化学 + 壳聚糖　； 参考：《东南大学》2017年硕士论文

【摘要】：水凝胶是由聚合物交联而成的具有三维空间网络结构的材料。壳聚糖及其衍生物因价格低廉易得、易降解及生物相容性好等优点,被广泛的应用到水凝胶材料的研究中。将水凝胶干燥得到复合膜材料,与传统方法制备的复合膜相比,壳聚糖衍生物复合膜的机械强度和物理化学性质更优良,且具有良好的抗菌效果,在生物材料领域有潜在的实际应用价值。金属配位化学是物理法制备水凝胶的方法之一,具有高效性、反应周期短、较好的官能团容忍度等优点。与传统物理方法制备水凝胶相比,金属离子交联配位克服了交联网络结构不规整、稳定性差和缺陷多的缺点。本文利用酰基化反应制备了一系列具有不同取代度的丁二酸酐酰化壳聚糖(NSCS),通过~1HNMR、FT-IR、XRD和元素分析对合成的化合物结构进行确认,证明其成功合成;通过金属离子与丁二酸酐酰化壳聚糖(NSCS)交联配位,及金属离子与丁二酸酐酰化壳聚糖(NSCS)-氧化石墨烯(GO)交联配位制备了一系列具有规整结构的水凝胶,再将所制备的水凝胶干燥后得到轻质、物理化学性能优良的复合膜,这是一种操作简便易行、绿色经济且全新的制备纳米复合膜的方法。利用SEM、XPS、TGA、溶胀率、稳定性、机械强度、抗菌性测试等对复合膜性能进行表征。其中本课题以锌离子配位制得的复合膜性能更加优良,当NSCS取代度为91.80%时,NSCS-Zn(Ⅱ)拉伸强度和杨氏模量达到119.3 MPa和2.67 GPa,NSCS-GO-Zn(Ⅱ)复合膜表现出优秀的机械性能,拉伸强度达到212.6±10.1 MPa,韧性为2.51 ±0.08 MJ/m3。高强度复合膜不仅有高的机械强度还具有良好的杀菌效果,其优异性能在医学材料领域有潜在的实际应用价值。
[Abstract]:Hydrogel is a material with three-dimensional network structure which is crosslinked by polymer. Chitosan and its derivatives have been widely used in hydrogel materials because of their advantages of low cost, easy degradation and good biocompatibility. The composite membrane material was prepared by drying the hydrogel. Compared with the traditional composite membrane, the chitosan derivative composite membrane has better mechanical strength and physical and chemical properties, and has a good antibacterial effect. It has potential application value in the field of biomaterials. Metal coordination chemistry is one of the physical methods for the preparation of hydrogels, which has the advantages of high efficiency, short reaction period and good tolerance of functional groups. Compared with the traditional physical method, metal ion crosslinking coordination overcomes the shortcomings of irregular crosslinking network structure, poor stability and many defects. In this paper, a series of succinic anhydride acylated chitosan (NSCS) with different degree of substitution were prepared by acylation reaction. The structure of the synthesized compounds was confirmed by XRD and elemental analysis. A series of hydrogels with regular structure were prepared by the crosslinking coordination of metal ions with succinic anhydride acylated chitosan (NSCS) and metal ions with succinic anhydride acylated chitosan (NSCS) -graphene oxide (GOO). After drying the prepared hydrogels, the composite membranes with light weight and excellent physical and chemical properties were obtained, which is a simple, convenient, green and new method for preparing nanocomposite membranes. The properties of the composite membrane were characterized by SEMX PSN TGA, swelling rate, stability, mechanical strength and antibacterial test. The composite film prepared by zinc ion coordination in this paper has better properties. When the degree of substitution of NSCS is 91.80, the tensile strength and Young's modulus of NSCS-Zn (鈪，

本文编号：1787215