由4-甲基-1,2,3-噻二唑-5-甲酸构筑的过渡金属配合物的合成、晶体结构及与DNA作用

发布时间：2018-04-24 07:59

本文选题：-甲基- + -噻二唑--甲酸　；参考：《无机化学学报》2017年08期

【摘要】：以4-甲基-1,2,3-噻二唑-5-甲酸(C_4H_4N_2O_2S,HL)分别与硫酸钴(CoSO_4·7H_2O)、氯化铜(CuCl_2·2H_2O)、硝酸银(AgNO_3)反应合成了3个配合物[Co(L)_2(H_2O)_4]·2H_2O(1)、[CuNa(L)_3]_n(2)和[AgL]_n(3),用元素分析、红外光谱、热重分析进行表征,用单晶X射线衍射测定了产物的结构。配合物1属于三斜晶系,空间群P1,Co~(2+)的配位数为6,形成一个略为拉长的CoN_2O_4八面体,与理想的正八面体非常接近。配合物2属于三斜晶系,空间群P1。Cu~(2+)离子的配位数为4,构成变形的平面四边形结构,Na~+离子的配位数为6,构成一个略微变形的八面体结构,最终形成三维网状结构。配合物3属于单斜晶系,空间群P21/c,银离子为三配位,构成变形的平面三角形构型,具有二维网状结构。用溴化乙锭荧光探针法测定了配体和配合物与DNA作用的荧光光谱。
[Abstract]:Three complexes [Co(L)_2(H_2O)_4] 2H _ 2O _ 1, [CuNa(L)_3] _ 2H _ 2O _ (2) and [AgL] _ n _ 3O _ 3 were synthesized by the reaction of C4H _ 4N _ 2O _ 2S _ 2S _ (hl) with Cobalt sulphate CoSO47H _ 2O, CuCl _ 2H _ 2O _ 3 and Agno _ 3, respectively. The products were characterized by elemental analysis, IR, TGA and X-ray diffraction. The coordination number of complex 1 is 6, which forms a slightly elongated CoN_2O_4 octahedron, which is very close to the ideal normal octahedron. The coordination number of the complex 2 belongs to the triclinic crystal system, the coordination number of the space group P1.Cu~(2) ion is 4, and the coordination number of the plane quadrilateral structure is 6, which forms a slightly deformed octahedron structure, and finally forms a three-dimensional network structure. Complex 3 belongs to monoclinic crystal system, space group P21 / c, silver ion is tri-coordinated, forming a plane triangular configuration with a two-dimensional network structure. The fluorescence spectra of ligands and complexes interacting with DNA were determined by ethidium bromide fluorescence probe method.
【作者单位】：浙江师范大学行知学院;浙江师范大学化学与生命科学学院;
【基金】：浙江省公益性技术应用研究计划项目(No.2014C32014)资助
【分类号】：O641.4

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