阳离子肽与多金属氧簇的协同组装

发布时间：2018-04-27 21:46

本文选题：阳离子肽 + 多金属氧簇　；参考：《吉林大学》2017年博士论文

【摘要】：多肽自组装形成的有序组装结构以及功能材料在药物释放、生物医学、组织工程等领域具有潜在的应用价值。而阳离子肽与功能性多阴离子的共组装不仅可以调节阳离子肽的组装结构,还可以进一步拓展阳离子肽的功能化应用,例如模拟天然的纳米结构、抗菌治疗、载药、基因转染、以及光动力治疗等。在本论文中,我们以阳离子肽和多金属氧簇为构筑基元,以阳离子肽与多金属氧簇的协同组装为出发点,通过对阳离子肽分子的优化和设计,借助阳离子肽与多金属氧簇在水溶液中的多重相互作用,构筑了可控的有序组装结构、生物活性材料、以及智能响应性凝胶材料。本论文主要取得如下进展:1.通过对阳离子肽分子的优化和设计,利用阳离子肽与多金属氧簇之间的多重相互作用,在水溶液中构筑了稳定的一维组装体,利用组装体表面的多价效应,提高了阳离子短肽的抗菌活性。利用组装体抵抗人血清中酶的降解能力,提高了阳离子短肽的生物稳定性。2.详细探究了阳离子肽与多金属氧簇之间协同组装的驱动力和机理,在水溶液中构筑了一维纳米纤维组装体和螺旋组装体,并探究了影响组装结构稳定性的因素。3.利用阳离子肽的组装能力以及多金属氧簇的氧化还原特性,实现了信息可重复擦写的智能响应性凝胶材料的构筑。以上研究工作揭示了阳离子肽与多金属氧簇在组装驱动力、组装结构、以及性质上的协同关系,这为胶体界面化学提供了新的发展空间和模型体系。
[Abstract]:The ordered assembly structure and functional materials of polypeptide self-assembly have potential application value in the field of drug release biomedicine tissue engineering and so on. The co-assembly of cationic peptide and functional polyanion can not only regulate the structure of cationic peptide, but also further expand the functional application of cationic peptide, such as imitating natural nanostructure, antimicrobial therapy, drug loading, gene transfection. And photodynamic therapy. In this thesis, cationic peptides and polyoxometallic clusters are used as the building units, and the cooperative assembly of cationic peptides and polyoxometalates is taken as the starting point, through the optimization and design of cationic peptide molecules. Based on the multiple interactions of cationic peptides and polyoxometalates in aqueous solution, controllable ordered assembly structures, bioactive materials and intelligent responsive gel materials were constructed. The main progress of this thesis is as follows: 1. Through the optimization and design of cationic peptide molecules, a stable one-dimensional assembly was constructed in aqueous solution by using the multiple interactions between cationic peptides and polyoxometalates, and the multivalent effect on the surface of the cationic peptides was utilized. The antibacterial activity of cationic short peptide was improved. The biostability of cationic short peptide was improved by using the assembly to resist the degradation of enzyme in human serum. The driving force and mechanism of synergistic assembly between cationic peptides and polyoxometalates were investigated in detail. One-dimensional nanofiber and helical assemblies were constructed in aqueous solution. Based on the assembly ability of cationic peptides and the redox properties of polyoxometallic clusters, an intelligent responsive gel material with repeatable information was constructed. The above studies reveal the synergistic relationship between cationic peptides and polyoxometalates in assembly driving force, assembly structure and properties, which provides a new development space and model system for colloidal interfacial chemistry.
【学位授予单位】：吉林大学
【学位级别】：博士
【学位授予年份】：2017
【分类号】：O648.17

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