光照条件下醋酸钯和有机光催化剂催化的C-H键活化反应研究

发布时间：2018-04-29 06:15

本文选题：AcrH_2-A + 有机光催化剂　；参考：《合肥工业大学》2017年硕士论文

【摘要】：辅酶是人体氧化还原反应中重要的物质,出现在细胞的很多代谢反应中。近年来,在化学反应中辅酶模型物受到越来越多的研究人员的关注。据报道,辅酶模型物可以参与很多化学反应,它可以替代一些金属催化剂,如运用辅酶模型物作为催化剂可以活化烯烃、还原α,β-环氧酮和α,β-不饱酮以及氧化含硫化合物。近年来,有机分子作为光催化剂利用单电子转移完成催化的途径越来越受到关注,AcrH2-A(10-乙基-9,10-二氢吖啶)作为一种辅酶模型物,它具有价格低廉、环境友好等优点,它可以作为一种光催化剂完成单电子转移过程。本文报道了AcrH2-A作为一种光催化剂,与具有导向作用的催化剂醋酸钯相互合作,形成双催化的C-H键活化的反应。AcrH2-A在蓝光的引发下可以使芳基四氟硼酸重氮盐形成芳基自由基,在醋酸钯的导向下与乙酰苯胺作用最终实现芳烃和芳基重氮盐的直接芳基化反应。它的反应条件温和,直接在室温的条件下进行,并且有很广泛的官能团兼容性。这项研究不仅仅是合成联芳烃的替代路线,而且它还是新的有机催化剂的应用。
[Abstract]:Coenzyme is an important substance in human redox reaction, which appears in many metabolic reactions of cells. In recent years, more and more researchers pay attention to coenzyme models in chemical reactions. It has been reported that coenzyme model compounds can take part in many chemical reactions and can replace some metal catalysts, such as activation of olefin, reduction of 伪, 尾 -epoxone and 伪, 尾 -unsaturated ketones and oxidation of sulfur-containing compounds using coenzyme model compounds as catalysts. In recent years, more and more attention has been paid to the application of single electron transfer in organic molecules as a coenzyme model material, which has the advantages of low cost and environmental friendliness. It can be used as a photocatalyst to complete the single electron transfer process. It is reported that AcrH2-A, as a photocatalyst, cooperates with palladium acetate as a direct catalyst to form a double catalytic C-H bond activation reaction. AcrH2-A can form aryl radical by aryl tetrafluoroboric acid diazo salt initiated by blue light. Under the guidance of palladium acetate and acetanilide, the aromatics and aryl diazo salts can be arylated directly. Its reaction conditions are mild, directly at room temperature, and have a wide range of functional compatibility. This study is not only an alternative route for the synthesis of biarenes, but also a new organic catalyst.
【学位授予单位】：合肥工业大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O621.251

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