手性伯胺-钯协同催化联烯的不对称端位加成

发布时间：2018-05-02 07:03

  本文选题：不对称 + 原子经济性　； 参考：《有机化学》2017年05期

【摘要】：正J.Am.Chem.Soc.2017,139,3631~3634不对称烯丙基化反应是构建立体选择性C—C键的重要策略之一,传统烯丙基化反应中由于离去基团的存在导致反应的原子经济性不高.联烯的加成反应可实现100%原子经济性的不对称烯丙基化反应.选择性地对联烯端位加成是不对称催化领域的挑战性课题.目前报道的策略大都是得到支链加成的烯丙基化产物,而且对映选择性较低,
[Abstract]:Asymmetric allylation is one of the most important strategies for constructing stereoselective C-C bond. In the conventional allylation reaction, the atom economy of the reaction is not high due to the presence of the leaving group in the conventional allylation reaction, I. e., the asymmetric allylation reaction of J.Am.Chem.Soc.2017139C3631C3634 is one of the important strategies for the construction of stereoselective C-C bond. The addition reaction of diene can realize the asymmetric allylation of 100% atom economy. Selective addition of end site to enene is a challenging subject in asymmetric catalysis field. At present, most of the reported strategies are to obtain allylation products with branched chain addition, and the enantioselectivity is low.
【分类号】：O621.251

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