大环芳烃功能化界面的构建及其手性响应性能的研究

发布时间：2018-05-04 05:05

本文选题：功能化界面 + 接触角　；参考：《华中师范大学》2016年硕士论文

【摘要】：随着人们对超分子化学的主客体化学的研究,界面上的手性识别已成为主客体化学的主要研究内容,尤其是界面上对客体液滴的静态和动态的研究,更是引起人们的广泛兴趣。功能化的手性界面对液体水滴的识别研究不仅具有宏观可视化的优势,而且选用的粗糙的硅界面还具有放大手性信号的作用。近年来,对界面识别的表征方法主要有浸润性、循环伏安法、元素分析法、阻抗和拉曼光谱等,但由于浸润性具有操作简单、宏观可视化、快速高效的优势,所以静态接触角、滚动角和接触角滞后已成为界面功能材料研究的主要表征方法。大环芳烃由于其独特的分子结构,在超分子化学的主客体系中表现出良好的识别性能,这为我们在界面上进行超分子化学的主客体系识别提供了良好的分子平台,而且通过界面的浸润性将界面的微观和宏观建立起统一的联系。我们对色谱分离的技术的研究多数在溶液中进行,那么,我们可否在功能化的手性界面上实现色谱分离技术的应用呢?基于上述思考,我们结合客体分子的结构特点,将杯芳烃和柱芳烃通过点击反应组装到硅界面上,从而构建具有特定分子的宏观响应性的功能化的手性界面。第一,我们根据布洛芬分子的结构特点,设计合成了杯[4]芳烃,通过点击反应,将杯芳烃组装到界面上,再通过静电相互作用,将精氨酸连接到界面上的杯芳烃上,成功的构筑了手性杯芳烃的功能化界面,然后通过静态接触角、滚动角和接触角滞后等测量,实现了该手性界面对布洛芬分子的宏观可视化的选择性识别。第二,我们根据ctDNA分子的结构特点,设计并合成了水溶性的手性丙氨酸柱[5]芳烃,通过点击反应和氢键相互作用力,将柱芳烃组装到硅界面上,成功的构筑了手性柱芳烃的硅界面。利用静态接触角、滚动角和接触角滞后测量,实现了该手性界面对ctDNA分子的宏观可视化识别。
[Abstract]:With the research of supramolecular chemistry, chirality recognition on interface has become the main research content of host-guest chemistry, especially the static and dynamic study of guest droplets on the interface, which has aroused people's extensive interest. The recognition of liquid droplets by functional chiral interface not only has the advantage of macroscopic visualization, but also has the function of amplifying chiral signals. In recent years, the characterization methods of interface recognition include wettability, cyclic voltammetry, elemental analysis, impedance and Raman spectroscopy, etc. Rolling angle and contact angle hysteresis have become the main characterization methods of interface functional materials. Because of their unique molecular structure, macrocyclic aromatic hydrocarbons exhibit good recognition performance in supramolecular chemistry system, which provides a good molecular platform for the recognition of supramolecular chemistry host and guest system at the interface. And through the wettability of the interface to establish a unified relationship between the micro and macro interface. Most of our researches on chromatographic separation are in solution, so can we realize the application of chromatographic separation technology on the functional chiral interface? Based on the above considerations, we combine the structural characteristics of the guest molecules and assemble calixarene and columnaromatics onto the silicon interface by click-through reaction, and then construct the functionalized chiral interface with the macroscopical response of a specific molecule. First, we designed and synthesized calix [4] aromatics according to the structural characteristics of ibuprofen molecules, assembled calixarene onto the interface by click-through reaction, and then connected arginine to calixarene at the interface by electrostatic interaction. The functionalized interface of chiral calixarene was successfully constructed, and the selective recognition of ibuprofen was realized by measuring the static contact angle, rolling angle and contact angle hysteresis. Secondly, according to the structural characteristics of ctDNA molecules, we have designed and synthesized water-soluble chiral alanine [5] aromatics, which are assembled on the interface of silicon by click-through reaction and hydrogen bond interaction. The silicon interface of chiral aromatics was successfully constructed. The static contact angle, rolling angle and contact angle lag measurement are used to realize the macroscopic visual recognition of ctDNA molecule by the chiral interface.
【学位授予单位】：华中师范大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：O625.1

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