基于席夫碱键的可注射糖肽水凝胶的制备及性能

发布时间：2018-05-04 18:33

本文选题：氧化葡聚糖 + 聚赖氨酸　；参考：《高等学校化学学报》2016年09期

【摘要】：以氧化葡聚糖(ODEX)和聚赖氨酸-聚乙二醇-聚赖氨酸(PLL24-PEG-PLL25)三嵌段聚合物为前驱体,通过ODEX中的醛基与PLL中的氨基之间的席夫碱键反应,制备了ODEX/PLL24-PEG-PLL25水凝胶.研究了其凝胶强度、降解时间及对阿霉素(DOX)释放量的影响.结果表明,随着ODEX中醛基密度的增加,凝胶强度逐渐增大,最大强度为3100 Pa.流变学研究结果表明,由于ODEX中的醛基与DOX中的氨基存在席夫碱键作用,导致凝胶强度从2160 Pa降至1730 Pa.降解实验结果表明,ODEX/PLL24-PEG-PLL25水凝胶具有较长的降解时间,最长时间达到29 d.药物释放结果表明,ODEX/PLL24-PEG-PLL25水凝胶具有酶促降解释放药物的性能.在Elastase溶液中,ODEX/PLL24-PEG-PLL25水凝胶所载DOX累积释放量达到最大值74.35%.结果表明,ODEX/PLL24-PEG-PLL25水凝胶具有进一步应用于体内局部药物传输的潜力.
[Abstract]:ODEX/PLL24-PEG-PLL25 hydrogels were prepared by the Schiff base bond reaction between the aldehyde group in ODEX and the amino group in PLL, using the triblock polymers of Poly (lysine-polyethylene glycol) and poly (lysine-polyethylene glycol) -PLL25) as precursors, using the oxidized dextran (ODEX) and poly (lysine-polyethylene glycol) -poly (ethylene glycol) (PLL24-PEG-PLL25) triblock polymers as precursors. The effects of gel strength, degradation time and the amount of DOX on the release of doxorubicin were studied. The results show that the gel strength increases gradually with the increase of aldehyde group density in ODEX, and the maximum strength is 3100 Pa. The rheological results show that the gel strength decreases from 2160 Pa to 1730 Paas due to the Schiff base bond between the aldehyde group in ODEX and the amino group in DOX. The results showed that the degradation time of ODEX / PLL24-PEG-PLL25 hydrogel was longer and the longest time was 29 days. The results of drug release showed that ODEX / PLL24-PEG-PLL25 hydrogel had the properties of enzymatic degradation and release of the drug. The cumulative release of DOX in ODEX / PLL24-PEG-PLL25 hydrogel reached a maximum value of 74.35 in Elastase solution. The results showed that ODEX / PLL24-PEG-PLL25 hydrogel had the potential for further application in local drug transport in vivo.
【作者单位】：长春工业大学化学工程学院高分子化学与物理系;中国科学院长春应用化学研究所生态环境高分子材料重点实验室;
【基金】：国家自然科学基金(批准号:21204081)资助~~
【分类号】：O648.17;TQ460.1

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