纤维素基水凝胶制备及性能研究

发布时间：2018-05-05 00:23

  本文选题：水凝胶 + 纤维素　； 参考：《南京大学》2017年硕士论文

【摘要】：水凝胶是一种特殊的"软"材料,它具有溶胀率高、机械强度大、生物相容性好和生物可降解等优点,在工业、农业、生物医学等领域均有广泛的应用。纤维素及其衍生物,因其来源丰富、可用性强等优点,常常被用来制备水凝胶。但传统方法制备的水凝胶存在一些缺点:机械性能差,溶胀率低等。本论文首先选取羟乙基纤维素(HEC),合成了半互穿网络结构的水凝胶,证实了其具有良好的机械性能。而后选取了羟丙基纤维素(HPC),合成了一种可注射水凝胶,证实了其具有生物相容性和生物可降解性。具体内容如下:1、首先我们针对传统水凝胶机械强度弱的问题,选用丙烯酸(AA)、木质素磺酸盐、羟乙基纤维素(HEC),通过原位聚合方法合成了一种半互穿网络结构的水凝胶(LS-A/H),并对水凝胶的机械性能、表面形貌、溶胀率等进行了研究。结果表明LS-A/H水凝胶是一种三维多孔网状结构高分子聚合物,内孔大小均一。LS-A/H水凝胶在不同pH环境下和不同的盐溶液中溶胀率有较大差异,可将其用来吸附有机染料或者重金属离子。同时LS-A/H水凝胶呈现了较好的机械性能,有望应用于组织工程领域。这种半互穿网络结构的水凝胶可操作性强,有较好的发展前景。同时也为木质素磺酸盐的使用找寻了新的方向,达到了我们设计的初衷。2、针对化学方法制备水凝胶存在部分毒性这一问题,我们选用羟丙基纤维素(HPC)、松香酸(AA)和牛血清蛋白(BSA)作为原料,合成了一种可注射型水凝胶(HPC-AA/BSA)。这种可注射型水凝胶初始状态为溶液,当调节环境的pH和温度,溶液内分子会以氢键方式结合形成三维网络交联结构。通过对水凝胶形成时间的测定,可得快速成凝胶的实验条件。通过对水凝胶形貌、流变性能、药物释放、细胞毒性等研究,发现此水凝胶具有安全性高、生物相容性好和生物可降解性好等特点。通过对水凝胶失水率测定,发现此水凝胶具有良好的保湿性能,可应用于面膜、眼膜等化妆品行业。本设计方案为合成可注射水凝胶提供了一个新思路,同时也拓展了可注射水凝胶在临床方面的应用。
[Abstract]:Hydrogel is a special "soft" material. It has many advantages such as high swelling rate, high mechanical strength, good biocompatibility and biodegradability. It is widely used in industry, agriculture, biomedicine and so on. Cellulose and its derivatives are often used to prepare hydrogels because of their rich sources and high availability. However, the hydrogels prepared by traditional methods have some disadvantages, such as poor mechanical properties, low swelling rate and so on. In this paper, hydrogels with semi-interpenetrating network structure were synthesized by HEC-hydroxyethyl cellulose (HEC) and proved to have good mechanical properties. Then, an injectable hydrogel was synthesized from HPC-HPC, which proved its biocompatibility and biodegradability. The specific contents are as follows: 1. First of all, in view of the problem of weak mechanical strength of traditional hydrogels, we select acrylic acid (AA), lignosulfonate (lignosulfonate), Hydroxyethyl cellulose (HEC) was synthesized by in-situ polymerization. The mechanical properties, surface morphology and swelling rate of the hydrogel were studied. The results show that LS-A/H hydrogel is a kind of three-dimensional porous polymer with network structure. The swelling rate of LS-A / H hydrogel with uniform inner pore size in different pH conditions and different salt solutions is different. It can be used to adsorb organic dyes or heavy metal ions. At the same time, LS-A/H hydrogels exhibit good mechanical properties, which are expected to be used in tissue engineering. The hydrogel with semi-interpenetrating network structure has strong maneuverability and good development prospect. It also provides a new direction for the use of lignosulfonate and achieves the original intention of our design. 2. In view of the problem of partial toxicity of hydrogels prepared by chemical methods, An injectable hydrogel (HPC-AA / BSAA) was synthesized by using hydroxypropyl cellulose (HPC), rosin acid (AAA) and bovine serum protein (BSA) as raw materials. The initial state of the injectable hydrogel is a solution. When the pH and temperature of the solution are adjusted, the molecules in the solution will combine in a hydrogen bond manner to form a three-dimensional network crosslinking structure. By measuring the formation time of hydrogels, the experimental conditions for rapid formation of hydrogels can be obtained. By studying the morphology, rheological properties, drug release and cytotoxicity of the hydrogel, it was found that the hydrogel had the characteristics of high safety, good biocompatibility and biodegradability. By measuring the water loss rate of hydrogel, it is found that the hydrogel has good moisturizing property and can be used in cosmetic industry such as facial mask and eye film. The design provides a new idea for the synthesis of injectable hydrogels and extends the clinical application of injectable hydrogels.
【学位授予单位】：南京大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O648.17
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本文编号：1845357