基于双稳态准轮烷的智能纳米容器的制备及其可控释放性能的研究

发布时间：2018-05-18 20:54

本文选题：柱芳烃 + 主客体复合物　；参考：《南京理工大学》2016年硕士论文

【摘要】：柱芳烃由于结构上的高度对称性和足够刚性的特点,成为继冠醚和环糊精后的第三代超分子主体化合物,故柱芳烃及衍生物的合成、分子识别以及应用逐渐成为超分子化学研究领域的热点。由柱芳烃作为大环主体化合物构筑的超分子纳米阀门已经被研究者争相报道,本文设计并制备一种柱芳烃主客体复合物构筑的超分子纳米阀门功能化的智能纳米容器,该纳米阀门能够封住纳米容器内部封装的缓蚀剂分子,苯并三氮唑(BTA)。具体研究工作如下：(1)合成主体大环超分子水溶性柱[5]芳烃(WP5)和1,6-(1-溴化己基吡啶)-己二胺(APy-HDA),这是APy-HDA作为具有两个结合位点的链状水溶性有机盐分子首例合成报道。随后,研究了在不同pH值下,WP5对APy-HDA的不同键合位点的分子识别行为,结果表明pH=7时,WP5通过静电作用和CH...π作用与APy-HDA结构中质子化了的HDA结构络合形成[2]准轮烷,随着pH的增加HDA结构去质子化,静电作用消失,WP5逐渐向APy-HDA结构中APy结构移动,此时CH...π作用是主要键合力。(2)设计制备基于柱芳烃主客体复合物的超分子纳米阀门功能化的介孔二氧化硅纳米颗粒(MSNs),通过透射电子显微镜(TEM),固体核磁共振波谱(SS NMR),傅里叶红外吸收光谱(FTIR),热重分析(TGA), X射线衍射分析仪(XRD), N2吸附脱附等温线等对其改性后的纳米容器进行结构表征,结果证明该种智能纳米容器已被成功制备,同时通过紫外-可见光谱(UV)对纳米容器中负载分子的动力学数据的测量,评价该纳米容器的可控释放能力,其结果为,负载分子的释放量占最大吸附量的比值分别为中性时38%,酸性时70%,碱性时高达90%,说明本文制备的纳米容器具有良好的可控释放效果。
[Abstract]:Because of its high symmetry in structure and sufficient rigidity, column aromatics have become the third generation supramolecular host compounds after crown ether and cyclodextrin. Molecular recognition and application have gradually become a hot spot in the field of supramolecular chemistry. Supramolecular nanovalves constructed by column aromatics as macrocyclic compounds have been reported by researchers. In this paper, an intelligent nanovessel with supramolecular nanovalves constructed by host and guest compounds of column aromatics has been designed and prepared. The nanovalve can seal the corrosion inhibitor molecule, benzotriazole BTAA, which is encapsulated inside the nanovessel. The main macrocyclic supramolecular water-soluble column [5] aromatics WP5) and 1-hexyl hexylpyridine-hexanediamine (APy-HDAA) were synthesized. This is the first report on the synthesis of APy-HDA as a chain water-soluble organic salt with two binding sites. Subsequently, the molecular recognition behavior of different binding sites of WP5 to APy-HDA at different pH values was studied. The results showed that at pH = 7, WP5 complexed with HDA structure in APy-HDA structure by electrostatic interaction and CH. 蟺 interaction to form [2] quasi rotorane. With the increase of pH, the HDA structure was deprotonated, the electrostatic action disappeared and WP5 gradually moved to the APy structure in the APy-HDA structure. At this time, Ch. 蟺 interaction is the main bonding force.) the supramolecular nano-valve based on the column aromatics host-guest complex was designed to prepare the mesoporous silica nanoparticles, which were functionalized by the mesoporous silica nanoparticles. The MSNs were prepared by transmission electron microscopy (TEM) and solid state magnetic resonance spectroscopy (SS-NMRs). The modified nanovessels were characterized by FTIR, thermogravimetric analysis (TGA), X-ray diffraction (XRD), N _ 2 adsorption and desorption isotherms. The results show that the intelligent nanovessel has been successfully prepared. At the same time, the dynamic data of the loaded molecules in the nanovessel are measured by UV-Vis spectroscopy, and the controllable release ability of the nanovessel is evaluated. The results are as follows: The ratios of the amount of loaded molecules to the maximum adsorption amount were 38 at neutral, 70 at acid and 90 at alkalinity, respectively, indicating that the nanovessel prepared in this paper has good controllable release effect.
【学位授予单位】：南京理工大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：O641.3

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