新型含杂环吡唑酰胺类化合物的合成及生物活性

发布时间：2018-05-19 03:02

本文选题：氯虫苯甲酰胺 + 杂环　；参考：《青岛科技大学》2017年硕士论文

【摘要】：杂环化合物往往具有广谱生物活性,大多数农药都具有杂环结构。吡唑酰胺类化合物由于其高效的生物活性而引起农药界人士的关注。在各类吡唑酰胺类化合物中,氯虫苯甲酰胺以其高效的杀虫活性、超长的持效期和对环境友好等特点,成为近年来农药关注的重点之一。以氯虫苯甲酰胺为母体,将杂环引入结构中进行结构改造,成为各大公司研究的热点,得到了一系列结构新颖并具有生物活性的化合物。本文通过查阅文献资料,对氯虫苯甲酰胺结构进行三个位点的改造,主要在三号位点结构中引入杂环,合成了一系列未见报道的新型杀虫剂。氯虫苯甲酰胺结构式以及改造后的新化合物结构式如下:本文设计合成了三个系列新型化合物:(1)含噻二唑吡唑酰胺类,(2)含VA二唑吡唑酰胺类,(3)含氨基吡啶吡唑酰胺类。对合成的新化合物通过核磁共振谱验证其结构,测试了杀虫活性,对生物活性优异的部分化合物进行了合成工艺的优化改进。三个系列新化合物结构式如下:
[Abstract]:Heterocyclic compounds often have broad-spectrum biological activity and most pesticides have heterocyclic structures. Pyrazolamide compounds have attracted much attention due to their high bioactivity. Among all kinds of pyrazolamide, chloramides have become one of the focuses of pesticide research in recent years because of their high insecticidal activity, long duration and environmental friendliness. A series of novel and bioactive compounds were obtained by introducing heterocycles into the structure of chloramides as the parent for structural modification. In this paper, the structure of chlorfenzoate benzoamide was modified with three sites by consulting literature. Heterocycles were introduced into the structure of site 3, and a series of new insecticides were synthesized. The structure formula of chlorobenzamide and the modified new compounds are as follows: in this paper, three series of novel compounds were designed and synthesized, including thiadiazolopyrazolamide (2) containing VA diazopyrazolamide (3) containing aminopyridine pyrazolamide. The structure of the new compounds was verified by nuclear magnetic resonance spectroscopy and the insecticidal activity was tested. Some of the compounds with excellent biological activity were optimized and improved. Three series of new compounds are structured as follows:
【学位授予单位】：青岛科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O626;TQ450.1

【参考文献】