三重串联四极杆电感耦合等离子体质谱法测定植源性中药材中总硫含量

发布时间：2018-05-19 11:33

本文选题：三重串联四极杆电感耦合等离子体质谱法(ICP-MS/MS) + 中草药　；参考：《光谱学与光谱分析》2016年02期

【摘要】：针对日益严重的植源性中药材中二氧化硫(SO_2)浓度超标问题,研究基于最新的三重串联四极杆电感耦合等离子体质谱(ICP-MS/MS)技术建立了一种快捷、准确的二氧化硫检测方法。该方法可以有效地降低背景中多原子离子的干扰,提高检测灵敏度与标准曲线的线性范围。使用氧气作为反应气,对~(32)S~(16) O_4~(2-)和~(34)S~(16) O_4~(2-)的检出限分别为5.48和9.76μg·L~(-1),线性范围0.02~100mg·L~(-1)(r0.999)。0.5g中药样品加入6mL硝酸和2mL双氧水,使用微波消解方式对样品进行消解。选用柑橘叶标准参考物质对方法的可靠性进行考察,样品平行处理测定6次后所得浓度值在标准值范围内。结果表明,本方法可以实现中草药中SO_2浓度的准确测定,样品处理过程以及样品中背景元素不会对定量结果的准确性产生干扰。
[Abstract]:Based on the latest three heavy series Quadrupole Inductively coupled plasma mass spectrometry (ICP-MS/MS), a fast and accurate method for detecting sulfur dioxide (SO_2) is established based on the latest three heavy series Quadrupole Inductively coupled plasma mass spectrometry (ICP-MS/MS). This method can effectively reduce the interference of polyatomic ions in the background and improve the detection. By using oxygen as reactant, the detection limits of ~ (32) S~ (16) O_4~ (2-) and ~ (34) S~ (16) O_4~ (2-) are 5.48 and 9.76 G. L~ (-1) using oxygen as reactant gas. The linear range 0.02~100mg. L~ (-1) samples are added to the nitric acid and hydrogen peroxide solution. The samples are eliminated by microwave digestion. The reliability of the standard reference material for citrus leaves was investigated. The concentration of the sample was within the standard range after 6 times of parallel processing. The results showed that the method could accurately determine the concentration of SO_2 in Chinese herbal medicine, and the process of sample treatment and the background elements in the sample would not interfere with the accuracy of the quantitative results.
【作者单位】：北京市疾病预防控制中心与北京市预防医学研究中心食物中毒诊断溯源技术北京市重点实验室;中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室;北京市顺义区疾病预防控制中心;
【基金】：国家自然科学基金项目(31301474) 国家科技支撑计划项目(2012BAK17B01) 北京市预防医学研究中心公益应用课题项目(2014-BJYJ-12)资助
【分类号】：R284;O657.63

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