离子液体中碘催化下2-氨基苯甲酰肼和4-氧代庚二酸的反应研究

发布时间：2018-05-27 19:57

本文选题：-氨基苯甲酰肼 + -氧代庚二酸　；参考：《有机化学》2017年12期

【摘要】：研究了以2-氨基苯甲酰肼和4-氧代庚二酸为原料,以离子液体为绿色溶剂,在碘催化下进行的反应.结果显示,当酰肼中与酰胺基相连上的N原子没有取代基时,会顺利构建三个新环生成哒嗪并[6,1-b]吡咯并[1,2-a]喹唑啉-1,6,9(7H)-酮衍生物,并通过X单晶衍射分析验证了产物2,3,4,5-四氢化-1H,9H-哒嗪并[6,1-b]吡咯并[1,2-a]喹唑啉1,6,9(7H)-三酮(3a)的结构.而当其取代基是芳基时,由于位阻效应,哒嗪环并没有如期关环,生成四氢吡咯并[1,2-a]喹唑啉-3a(1H)-丙酸衍生物.该方法具有合成路线简洁、溶剂绿色环保、操作简便且收率较高等优点.
[Abstract]:The reaction of 2-aminobenzoic hydrazide and 4-oxoheptanedioic acid with ionic liquid as green solvent catalyzed by iodine was studied. The results show that three new rings can be successfully constructed to form pyridazines [61-b] pyrrorolidone [1aniline] quinazoline -1zolidoline -16N ~ (9) H ~ (-) -one derivatives when the N atom attached to the amide group in acyl hydrazide does not have a substituent group. The structure of the product 2O3O3O4O4HZO5HZO9H-pyridazinopyrrolidone [1O2-a] Quinazoline (1H) was confirmed by X-ray single crystal diffraction analysis, and the structure of the product was characterized by X-ray diffraction. The structure of the product was also studied. The structure of the product was characterized by X-ray diffraction. The structure of the product was characterized by X-ray diffraction. When the substituted group is aryl, the pyridazine ring does not close the ring as scheduled due to the steric resistance effect. The method has the advantages of simple synthesis route, green solvent, simple operation and high yield.
【作者单位】：江苏徐州甘薯研究中心中国农业科学院甘薯研究所;
【基金】：国家现代农业产业技术体系建设专项资金(No.CARS-10-B20)资助项目~~
【分类号】：O621.251

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