手性金属—有机骨架材料用作高效液相色谱手性固定相研究

发布时间：2018-05-28 00:24

本文选题：手性金属-有机骨架材料 + 高效液相色谱　；参考：《云南师范大学》2017年硕士论文

【摘要】：手性金属-有机骨架材料作为一种新型的功能材料,因其具有手性孔道、高的比面积、可修饰的孔道表面以及结构多样性等特点,使其在气体吸附、分离和催化等众多领域有着广泛的应用。最近,有很多工作者致力于金属-有机骨架材料在色谱固定相中的研究,但将手性MOFs用作高效液相色谱手性固定相的数量还为数不多。本论文主要工作如下:1、通过溶剂热法合成了一种具有三维手性网状结构的MOF[Cu(S-mal)(bpy)]_n,并将其用作固定相制成高效液相色谱手性柱用于外消旋化合物和位置异构体的分离。讨论了色谱条件对[Cu(S-mal)(bpy)]_n手性柱分离性能的影响。实验结果表明,该手性柱对17种外消旋化合物和3种位置异构体表现了较好的分离能力。最后还考察了该手性柱的重现性和稳定性。2、以S-苹果酸为配体合成了两种手性MOFs[Cu(S-mal)(bpe)]_n和[Ni(S-mal)(bpy)]_n,将它们用作高效液相色谱固定相对外消旋化合物进行分离。实验结果表明[Cu(S-mal)(bpe)]_n手性柱对16种外消旋化合物表现出较好的拆分能力;[Ni(S-mal(bpy)]_n手性柱对6种外消旋化合物得到不同程度的分离。3、合成了三种手性MOFs[Co(L)(bpe)_2(H_2O)_2]·H_2O、[Zn(S-nip)_2]_n和{[Co(S-nip)_2]·(H_2O)_(0.5)}n用作高效液相色谱固定相分离外消旋化合物。实验结果表明:在正相色谱条件下,外消旋化合物在三种手性MOFs柱上得到不同程度的拆分。因此,将合成的三种晶体用作高效液相色谱手性固定相具有一定的理论意义和应用前景。
[Abstract]:As a new functional material, chiral metal-organic skeleton materials are adsorbed on gas due to their chiral pores, high specific area, modified pore surfaces and structural diversity. Separation and catalysis are widely used in many fields. Recently, many researchers have been devoted to the study of metal-organic matrix materials in chromatographic stationary phase, but the number of chiral MOFs used as chiral stationary phase in HPLC is still few. The main work of this thesis is as follows: 1. A novel MOF with three-dimensional chiral network structure was synthesized by solvothermal method. It was used as a stationary phase to prepare a chiral column for the separation of racemic compounds and position isomers. The effect of chromatographic conditions on the separation performance of [CuPS-malbpy] tip-n chiral column was discussed. The experimental results show that the chiral column has good separation ability for 17 racemic compounds and 3 position isomers. Finally, the reproducibility and stability of the chiral column were also investigated. Two chiral MOFs (CuS-malobpe) and [NiNiS-malbpy)] were synthesized with Smalic acid as ligand and used as stationary relative racemic compounds in high performance liquid chromatography (HPLC). The experimental results show that the chiral column has better resolution ability for 16 racemic compounds; [Niels-malbpy)] the chiral column can separate 6 racemic compounds to varying degrees, and three chiral MOFs [Co(L)(bpe)_2(H_2O)_2] H _ 2O, [Zn(S-nip)_2] n and {[Co(S-nip)_2] H2O-S _ 2O _ (0.5)] n have been synthesized for high performance liquid chromatography (HPLC). Stationary phase separation of racemic compounds. The results showed that racemic compounds were separated on three chiral MOFs columns under normal phase chromatography. Therefore, the synthesis of three kinds of crystals as chiral stationary phase in high performance liquid chromatography has certain theoretical significance and application prospect.
【学位授予单位】：云南师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O652.63;TB34

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