二苯丙氨酸二肽有序纳米结构的组装及应用

发布时间：2018-06-09 23:11

本文选题：二苯丙氨酸 + 自组装　；参考：《科学通报》2017年06期

【摘要】：二苯丙氨酸二肽(L-Phe-L-Phe,FF)是引起阿尔兹海默症的A?-多肽成纤维的关键识别序列,具有优异的自组装性能,是制备生物功能性纳米材料的重要组装基元.迄今为止,研究者已制备出多种FF基微纳米结构,但是如何有效地控制自组装材料的形状和尺寸一直都是研究的关键和热点.近年来,本课题组通过改变组装条件以及引入外源小分子等方法来调控FF基肽分子的组装,成功实现了对肽基组装材料的形状、结构和功能的调控.这些研究不仅丰富了FF基肽分子的组装结构,同时也为其他肽基纳米材料的制备和生物功能材料的开发提供了新的策略和重要的实验依据.
[Abstract]:Diphenylalanine dipeptide L-Phe-L-Phe-FFF is the key recognition sequence of A1-polypeptide fibroblasts causing Alzheimer's disease. It has excellent self-assembly properties and is an important assembly unit for the preparation of biofunctional nanomaterials. So far, researchers have prepared a variety of FF-based microstructures, but how to effectively control the shape and size of self-assembled materials has been the key and focus of research. In recent years, our team has successfully regulated the shape, structure and function of peptide based assembly materials by changing the assembly conditions and introducing exogenous small molecules to control the assembly of FF peptide molecules. These studies not only enrich the assembly structure of FF-based peptides, but also provide a new strategy and important experimental basis for the preparation of other peptide based nanomaterials and the development of biological functional materials.
【作者单位】：中国科学院化学研究所;中国科学院大学;
【基金】：国家自然科学基金(21433010,21320102004,21321063,21303221) 国家重点基础研究发展计划(2013CB932802)资助
【分类号】：O629.72

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