新型含取代四氮唑环结构的吡唑肟类化合物的合成与生物活性研究

发布时间：2018-06-10 05:21

本文选题：四氮唑 + 吡唑肟　；参考：《有机化学》2017年12期

【摘要】：为了从吡唑肟类化合物中寻找新的活性物质,采用活性基团拼接原理,设计制备了一系列未见文献报道的新型含取代四唑环结构的吡唑肟类衍生物.借助于~1H NMR、~(13)C NMR和元素分析等手段对所合成化合物的结构进行了确证.对目标化合物进行了初步的生物活性测定,结果显示部分化合物具有较好的杀虫活性.在测试浓度为500μg/m L时,10个化合物对粘虫的杀死率可达90%~100%,9个化合物对蚜虫的杀死率可达80%~100%,10个化合物对褐飞虱的杀死率可达80%~100%,1个化合物对朱砂叶螨的杀死率为80%.当测试浓度降至100μg/m L时,1个化合物对蚜虫的杀死率为85%.此外,某些化合物还呈现出一定的杀菌活性.在测试浓度为200μg/m L时,2个化合物对黄瓜霜霉病菌的抑制率可达60%~80%.
[Abstract]:In order to find new active substances from pyrazoloxime compounds, a series of novel pyrazoloxime derivatives containing substituted tetrazole ring structure were designed and prepared by using the principle of active group splicing. The structure of the synthesized compounds was confirmed by means of ~ (13) C NMR and elemental analysis. The results showed that some of the target compounds had good insecticidal activity. At the test concentration of 500 渭 g / mL, the killing rate of 10 compounds to the armyworm reached 90%, the killing rate of 9 compounds to the aphids reached 80%, the killing rate of 10 compounds to the brown planthopper reached 80%, and the killing rate of one compound to the leaf mites cinnabar was 80%. When the test concentration was reduced to 100 渭 g / mL, the killing rate of one compound to aphid was 85%. In addition, some compounds also showed certain bactericidal activity. At the concentration of 200 渭 g / mL, the inhibition rate of the two compounds against downy mildew of cucumber reached 60% and 80% respectively.
【作者单位】：南通大学化学化工学院;南通大学分析测试中心;
【基金】：国家自然科学基金(No.21372135) 江苏省“六大人才高峰”(No.2013-SWYY-013) 江苏省研究生实践创新计划(No.SJCX17_0640)资助项目~~
【分类号】：O626.2

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