NHMA改性PNIPAM微凝胶的制备与正温度响应效应研究

发布时间：2018-06-16 15:44

  本文选题：N-异丙基丙烯酰胺 + N-羟甲基丙烯酰胺　； 参考：《哈尔滨工业大学》2017年硕士论文

【摘要】：温度敏感型聚合物作为有效的药物载体,可以实现药物在外界信号作用下的控制释放。其中聚N-异丙基丙烯酰胺(PNIPAM)是一种较为常见和应用较多的温敏材料,将其制备成为微凝胶形态并实现正温度响应效应的释放作用,意义明显。本文用乳液聚合法制备PNIPAM微凝胶,在交联剂用量为0.03g、0.05g、0.07g、0.09g、0.11g条件下制备微凝胶试样,考察交联剂用量与PNIPAM微凝胶粒径的关系。引入N-羟甲基丙烯酰胺(NHMA)单体,制备共聚的P(NIPAM-co-NHMA)微凝胶,通过设置交联剂用量为0.01g、0.02g、0.03g、0.04g、0.05g和表面活性剂用量为0.01g、0.02g、0.03g、0.05g获得两组微凝胶试样,考察交联剂和表面活性剂的用量与P(NIPAM-co-NHMA)微凝胶粒径的关系;进一步考察NHMA对共聚微凝胶最低临界溶解温度(LCST)的影响,其中NIPAM:NHMA的质量比分别为1.5:0、1.4:0.1、1.3:0.2、1.2:0.3、1.1:0.4,结果表明共聚微凝胶的LCST值调节在33℃~40℃之间。采用FT-IR确定了均聚和共聚微凝胶的组成;采用扫描电镜和透射电镜观测均聚和共聚微凝胶的微观形貌和粒径。在获得均聚和共聚微凝胶的基础上,考察交联剂用量、微凝胶溶液浓度、p H值、Na Cl和表面活性剂(SDS)等因素对微凝胶LCST值的影响,结果表明SDS使微凝胶的LCST值升高,酸和碱使微凝胶的LCST值降低,交联剂用量、微凝胶溶液浓度和Na Cl不影响微凝胶的LCST值。以罗丹明B为模型药物,以双组份的聚二甲基硅氧烷为成膜基质,通过流延成膜法制备了负载微凝胶的复合体系,考察了30℃和45℃时薄膜对罗丹明B的释放量。当温度高于微凝胶粒子的LCST值时,微凝胶粒子体积会收缩,会有孔隙出现,从而罗丹明B通过薄膜的释放量增加。表明薄膜能够实现正向温度控制释放,且随着薄膜中凝胶粒子复合量的增加,以及随着薄膜厚度减小,罗丹明B释放速率相应增加。
[Abstract]:As an effective drug carrier, temperature-sensitive polymers can realize controlled release of drugs under the action of external signals. Poly (N- isopropylacrylamide) (PNIPAM) is a common and widely used thermo-sensitive material. It is of great significance to prepare it into microgel form and realize the release of positive temperature response effect. In this paper, PNIPAM microgel was prepared by emulsion polymerization. The microgel samples were prepared under the condition of 0.03g / 0.05g ~ 0.07g ~ 0.07g ~ (0.07g) ~ (0.11) g / g crosslinking agent. The relationship between the amount of crosslinking agent and the particle size of PNIPAM microgel was investigated. The copolymerized PNIPAM-co-NHMA-microgel was prepared by introducing N-hydroxymethylacrylamide (NHMA) monomer. Two groups of microgel samples were obtained by setting the amount of crosslinking agent 0.01g / g (0.02g / g) 0.03g / (0.03g / g) and the amount of surfactant 0.01g / 0.02g / g / 0.03g / 0.05g respectively. The relationship between the amount of crosslinking agent and surfactant and the particle size of PNIPAM-co-NHMA microgel was investigated, and the effect of NHMA on the minimum critical solution temperature (LCST) of copolymer microgel was investigated. The mass ratio of NIPAM: NHMA is 1.5: 0: 1.4: 0.1: 1.3: 1.2: 0.2: 1.1: 0.4. The results show that the LCST value of copolymerized microgel is adjusted between 33 鈩，

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