杂双金属复合物ZABDP催化芳香酮与芳香醛的直接不对称Aldol反应

发布时间：2018-06-22 17:36

本文选题：不对称合成 + 不对称催化　；参考：《高等学校化学学报》2017年05期

【摘要】：合成了新型的手性铝/锌杂双金属复合物(R,S,S)-3,3'-二[(N-二苯基脯氨醇)甲基]-2,2'-二羟基-1,1'-联萘酚铝/锌复合物(ZABDP).在催化芳香酮与芳香醛的羟醛缩合(Aldol)反应中,该复合物中的铝作为路易斯酸活化醛,锌的烷氧化物作为Br?nsted碱,使苯乙酮形成活性锌的烯醇化物,2种金属的应用使得芳香醛与芳香酮的直接不对称Aldol反应顺利进行,反应的对映选择性最高达90%,产率最高达99%.
[Abstract]:A novel chiral aluminum / zinc heterobimetallic complex (RPS-3) -3- (N- diphenyl proline)-methyl] -2- (dihydroxyproline) -dihydroxy-1 (1) -binaphthol aluminum / zinc complex (ZABDP) has been synthesized. In the (Aldol) condensation of aromatic ketones with aromatic aldehydes, aluminum in the complex is used as Lewis acid to activate aldehydes, and zinc alkoxides as Brnsted bases. The direct asymmetric Aldol reaction between aromatic aldehydes and aromatic ketones was carried out smoothly by the application of enolides which gave acetophenone active zinc. The enantioselectivity of the reaction was up to 90 and the yield was up to 9999.
【作者单位】：榆林学院化学与化工学院;兰州大学生命科学学院生物化学与分子生物学研究所;
【基金】：国家自然科学基金(批准号:20672051,21072087) 榆林市科学技术局基金(批准号:2014Cxy-01)资助~~
【分类号】：O621.251

【相似文献】