光催化含氮化合物的全氟烷基化反应

发布时间：2018-06-22 22:00

本文选题：可见光催化 + 腙　；参考：《安徽理工大学》2017年硕士论文

【摘要】：有机氟化合物独特的物理化学性质在染料、聚合物、农用化学品、药品和功能材料等领域有着广泛的应用。引入全氟基团能够增强分子的结合选择性,提高亲油性,或改善代谢稳定性。过去全氟化一般使用过渡金属催化剂,比如Pd和Cu。可见光催化全氟化是一种新颖的合成方式,而且是一种温和的,高效率,宽范围的新颖合成方法,由于其环境友好,操作简便,易获得等诸多的优点,受到人们越来越多的关注。另外含氮有机化合物具有独特的生物活性,在工业生产及日常生活占有重要的地位。本文通过光催化将全氟碘烃基和三氟甲基引入含氮化合物(腙)中,进行了腙的全氟烷基化反应研究。主要内容包括以下两个部分:1、对可见光诱导全氟烷基化反应背景及发展状况进行了介绍,并阐述了本文的研究内容和创新点。2、研究了以全氟碘代烷烃为全氟烷基化试剂,筛选了可见光催化的反应最优条件,对多种类型的腙进行全氟烷基化,并对全氟烷基化产物的立体构型,反应机理进行了研究,对反应机理的研究表明该反应是光诱导的自由基型反应。
[Abstract]:The unique physical and chemical properties of organic fluorides are widely used in the fields of dyes, polymers, agricultural chemicals, pharmaceuticals and functional materials. Introduction of perfluoro groups can enhance molecular binding selectivity, improve lipophilicity, or improve metabolic stability. In the past, transition metal catalysts such as PD and Cu were used in perfluorination. Visible photocatalytic perfluorination is a novel synthesis method, and it is a mild, high efficiency, wide range of novel synthesis method, because of its environmental friendly, easy to operate, easy to obtain and many other advantages. Get more and more attention. In addition, nitrogen-containing organic compounds have unique biological activity and play an important role in industrial production and daily life. In this paper, perfluoroalkylation of Hydrazone with perfluoroiodoalkyl and trifluoromethyl was studied by photocatalysis. The main contents include the following two parts: 1. The background and development of the visible light-induced perfluoroalkylation reaction are introduced. The research contents and innovations of this paper are described, and the perfluoroiodinated alkanes as perfluoroalkylation reagents are studied. The optimum reaction conditions for visible light catalysis were screened, and the perfluoroalkylation of various types of Hydrazone was carried out, and the stereoscopic configuration and reaction mechanism of perfluoroalkylation products were studied. The study of reaction mechanism shows that the reaction is a radical type reaction induced by light.
【学位授予单位】：安徽理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O621.251

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