壳聚糖改性及其纳米微球制备表征

发布时间：2018-06-23 01:41

  本文选题：壳聚糖 + N-琥珀酰化　； 参考：《长春大学》2017年硕士论文

【摘要】：壳聚糖作为可降解和再生的高分子材料而备受关注,而壳聚糖固有特性的不足限制了其应用,各种改性手段被用来对壳聚糖结构中活泼的多羟基和氨基官能团进行修饰,以增强壳聚糖的应用性。近年来,纳米材料的研究成为热点,壳聚糖纳米材料与其他人工高分子材料相比优点较为突出。同时经由壳聚糖为主要原料制备的膜材料在农业、医药、环保等方面被广泛应用。本文以壳聚糖为研究对象,通过对其改性、纳米化、膜处理后,进一步优化制备工艺从而提高其应用价值,具体研究内容如下:(1)本论文通过丁二酸酐与壳聚糖发生酰化反应,由IR光谱图分析得证酰化反应最终在壳聚糖分子结构的N-位成功引入琥珀酰基,在二甲基亚砜体系中制备获得改性的N-琥珀酰壳聚糖。制备得到N-琥珀酰壳聚糖的脱乙酰度达到0.63。溶解性实验表明N-琥珀酰壳聚糖的水溶解性能明显强于壳聚糖。(2)利用壳聚糖和实验获得的N-琥珀酰壳聚糖为原料,依据离子诱导法获得壳聚糖纳米和N-琥珀酰壳聚糖纳米粒,对制备过程中的影响因素进行了实验分析。并对两种纳米粒子同时进行表征后对比研究性状不同之处,实验条件下制备的N-琥珀酰壳聚糖纳米粒体系较为稳定,从电镜照片可观察出纳米粒的形态完整,分散性良好,平均粒径为195nm。(3)实验利用流延法分别获得了壳聚糖膜、N-琥珀酰壳聚糖膜。实验以机械性能为指标,获得了壳聚糖膜的最优制取工艺:壳聚糖浓度2%、碱处理时间3h、烘干温度50℃、烘干时间4h。红外光谱表明甘油的加入并没有改变壳聚糖分子的内部结构,但甘油可明显改善膜的延展性,从而最大限度地在复合膜中保留了壳聚糖良好的生物特性。
[Abstract]:Chitosan, as a biodegradable and regenerated polymer material, has attracted much attention. However, its application is limited by the inherent characteristics of chitosan. Various modification methods have been used to modify the active polyhydroxyl and amino functional groups in the structure of chitosan. To enhance the application of chitosan. In recent years, the research of nano-materials has become a hot spot. Chitosan nano-materials have more advantages than other artificial polymer materials. Meanwhile, membrane materials prepared by chitosan are widely used in agriculture, medicine, environmental protection and so on. In this paper, chitosan was used as the research object. After modification, nanocrystalline and membrane treatment, the preparation process was further optimized to improve its application value. The specific research contents were as follows: (1) the acylation reaction between chitosan and succinic anhydride was carried out in this paper. The IR spectra showed that the succinyl group was successfully introduced into the N-site of chitosan molecular structure and the modified N-succinyl chitosan was prepared in the system of dimethyl sulfoxide (DMSO). The degree of deacetylation of N-succinyl chitosan was 0.63. The solubility test showed that the solubility of N- succinyl chitosan was better than that of chitosan. (2) chitosan nanoparticles and N- succinyl chitosan nanoparticles were obtained by ion induction method using chitosan and N- succinyl chitosan as raw materials. The influencing factors in the preparation process were analyzed experimentally. The N- succinyl chitosan nanoparticles prepared under the experimental conditions were stable, and the morphology and dispersity of the nanocrystalline grains could be observed by electron microscope photographs. The average particle size was 195 nm. (3) the chitosan membrane was obtained by the method of flow extension, and the N-succinyl chitosan membrane was obtained. The optimum preparation process of chitosan membrane was obtained by taking mechanical properties as index: chitosan concentration 2, alkali treatment time 3 h, drying temperature 50 鈩，

本文编号：2055165