氮杂环卡宾催化的氰基甲酸乙酯与醛亚胺的Strecker反应研究

发布时间：2018-06-24 05:20

  本文选题：氮杂环卡宾 + Strecker反应　； 参考：《有机化学》2017年04期

【摘要】：以四氢呋喃为溶剂,氮杂环卡宾为催化剂,进行了氰基甲酸乙酯和亚胺的Strecker反应研究.实验中考察了催化剂的种类、用量及溶剂对反应的影响,确定了最优反应条件.结果显示氰基甲酸乙酯与芳香亚胺、脂肪亚胺都能发生Strecker反应,最终合成了14个α-氨基腈衍生物,产物产率最高达到93%.该反应具有操作简单,条件温和,产率高及环境友好等优点.
[Abstract]:The Strecker reaction of ethyl cyanate and imine was studied using tetrahydrofuran as solvent and heterocyclic carbene as catalyst. The effects of catalyst type, dosage and solvent on the reaction were investigated, and the optimum reaction conditions were determined. The results showed that 14 伪 -aminonitrile derivatives were synthesized by Strecker reaction of ethyl cyanate with aromatic imines and aliphatic imines. The highest yield of the products was 933%. The reaction has the advantages of simple operation, mild conditions, high yield and environmental friendliness.
【作者单位】： 石河子大学化学化工学院新疆兵团化工绿色过程重点实验室-省部共建国家重点实验室培育基地;
【基金】：国家自然科学基金(No.21262027)资助项目~~
【分类号】：O621.251
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本文编号：2060205