基于分子印迹聚合物掺杂氧化石墨烯膜的利巴韦林电位传感器

发布时间：2018-06-24 23:50

本文选题：利巴韦林 + 印迹聚合物　；参考：《分析化学》2017年07期

【摘要】：以利巴韦林为模板分子,甲基丙烯酸为功能单体,采用沉淀聚合法制备利巴韦林分子印迹聚合物(MIP)。以利巴韦林分子印迹聚合物掺杂氧化石墨烯(GO)为离子载体,聚氯乙烯为基质,癸二酸二辛酯为增塑剂制备电极敏感膜。结果表明,敏感膜组成为100.8 mg MIP、14.7 mg GO、450.8 mg聚氯乙烯和901.6 mg癸二酸二辛酯,内充液组成为0.1 mol/L NaCl+0.05 mol/L Na Ac-0.05 mol/L HAc缓冲溶液+1.0×10~(-5)mol/L利巴韦林,电极的响应性能最好。此电极的能斯特响应斜率为45.565 m V/decade,线性范围为1.0×10~(-6)~1.0×10~(-4)mol/L,检出限为1.0×10~(-7)mol/L(S/N=3),工作p H范围为3~5,响应时间小于3 min。此电极对利巴韦林具有高选择性,可用于检测饲料和注射液中利巴韦林含量,加标回收率为90%~110%,RSD为3.0%~7.9%。
[Abstract]:Ribavirin molecularly imprinted polymer (MIP) was prepared by precipitation polymerization with ribavirin as template molecule and methacrylic acid as functional monomer. The electrode sensitive membrane was prepared with ribavirin molecularly imprinted polymer doped graphene oxide (go) as ionic carrier, polyvinyl chloride as matrix and dioctyl sebacate as plasticizer. The results showed that the sensitive membrane was composed of 100.8 mg MMP 14.7 mg GOP 450.8 mg PVC and 901.6 mg dioctyl Sebacate, and the composition of the inner solution was 0.1 mol / L NaCl 0.05mol / L Na Ac-0.05 mol / L HAC buffer solution 1.0 脳 10 ~ (-5) mol / L ribavirin. The electrode had the best response performance. The Nernst response slope of the electrode is 45.565 MV / L, the linear range is 1.0 脳 10 ~ (-6) ~ (-6) ~ (-1) 脳 10 ~ (-4) mol / L, the detection limit is 1.0 脳 10 ~ (-7) mol / L (S / N ~ (3), the working pH range is 3 ~ 5, and the response time is less than 3 min. The electrode has high selectivity to ribavirin, and can be used for the determination of ribavirin in feed and injection. The recovery of ribavirin in feed and injection is 90% and 110% (RSD = 3.0%).
【作者单位】：广东食品药品职业学院;肇庆学院化学化工学院;
【基金】：广东省医学科研基金项目(No.2016369) 广东食品药品职业学院科研基金肇庆市科技计划项目(No.2015B010301002)资助
【分类号】：O657.1;TP212

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