基于酒石酸和苹果酸多重芳基化—环化反应的初步研究

发布时间：2018-07-04 23:33

本文选题：生物质 + 串联反应　；参考：《东北师范大学》2017年硕士论文

【摘要】：茚满酮类化合物种类繁多,具有抗高血压、抗恶性肿瘤、抗阿尔茨海默病等生物活性,茚满酮类化合物的多样性合成是有机化学的研究热点之一。虽然,迄今为止对此类化合物合成方法的研究较多,但绿色、实用的合成方法仍有待开发。倡导和实践绿色化学理念是实现可持续发展的必经之路。随着人们对可持续发展和绿色化学理念认识的不断提高,多组分反应、串联反应及可再生资源的合理利用已在化学及相关领域得到快速发展。近年来,将可再生资源(如生物质化合物)的合理利用与串联反应相融合的合成方法研究引人关注,将生物质资源的合理利用与多组分反应及串联反应相融合的合成方法研究符合绿色与可持续化学的要求,具有重要的研究和应用价值。本论文以开发可再生生物质化合物的多组分串联反应为目标,以生物质二元羧酸的多重芳基化-环化反应为主线开展生物质资源与多组分反应及串联反应相融合的合成方法研究。以简单易得的酒石酸和苹果酸为原料,在超酸的作用下,通过串联多重芳基化-环化反应,得到了一系列茚满酮类化合物。产物结构均通过1H-NMR、13C-NMR、质谱等数据的证实。同时,对该反应的反应机理也做了初步的探讨。
[Abstract]:Indanone compounds have many kinds of biological activities such as anti-hypertension, anti-malignant tumor, anti-Alzheimer 's disease and so on. The diversity synthesis of ninemone compounds is one of the research hotspots in organic chemistry. Although so far more researches have been done on the synthesis of this kind of compounds, green and practical synthetic methods have yet to be developed. Advocating and practicing the concept of green chemistry is the only way to realize sustainable development. With the increasing understanding of the concept of sustainable development and green chemistry, the multicomponent reaction, tandem reaction and rational utilization of renewable resources have been developed rapidly in chemistry and related fields. In recent years, the research on the synthesis method of integrating the rational utilization of renewable resources (such as biomass compounds) with tandem reactions has attracted much attention. The study on the synthesis method of combining the rational utilization of biomass resources with multicomponent reaction and series reaction accords with the requirements of green and sustainable chemistry and has important research and application value. The aim of this thesis is to develop multicomponent series reaction of renewable biomass compounds. Based on the multi-arylation and cyclization reaction of biomass dicarboxylic acid, the synthesis method of biomass resources fusion with multi-component reaction and series reaction was studied. A series of indolemone compounds were synthesized by series arylation-cyclization reaction with simple and easily available tartaric acid and malic acid under the action of superacid. The structure of the product was confirmed by 1H-NMR-13C-NMR-MS. At the same time, the reaction mechanism is also discussed.
【学位授予单位】：东北师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O621.256.9

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