一种合成二氢黄酮醇衍生物的简易方法

发布时间：2018-07-05 19:18

本文选题：一种 + 合成　；参考：《有机化学》2016年11期

【摘要】：以2'-羟基查尔酮衍生物为原料,在低温条件下,以四氢呋喃为溶剂,在H_2O_2/(C_2H_5)_2NH体系中,高收率地实现一系列二氢黄酮醇类衍生物的合成.考查了反应温度、反应溶剂、碱添加剂的种类和比例以及氧化剂的种类和比例对该反应的影响,确定了最优反应条件.此合成方法具有操作简单、条件温和及后处理方便等特点.此外,所合成产物的结构经核磁共振谱表征确证.
[Abstract]:A series of dihydroflavonol derivatives were synthesized in high yield in the H _ 2O _ 2 / (C _ 2H _ 5) _ 2NH system by using 2-hydroxy-chalcone derivatives as raw materials and tetrahydrofuran as solvent at low temperature. The effects of reaction temperature, solvent, type and proportion of alkali additive and oxidant on the reaction were investigated, and the optimum reaction conditions were determined. The synthetic method is characterized by simple operation, mild conditions and convenient post-processing. In addition, the structure of the synthesized product was confirmed by nuclear magnetic resonance spectroscopy.
【作者单位】：湖北中医药大学药学院中药化学与中药资源省级重点实验室;
【基金】：国家自然科学基金(No.31370378)资助项目~~
【分类号】：O621.3

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