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罗丹明和香豆素类金属离子荧光探针的合成及光谱性能研究

发布时间:2018-07-17 07:04
【摘要】:在生命体系中,金属离子参与了各项生理和病理过程,金属离子只能维持在一定的浓度才能保证正常的生命活动。为了更好的研究其生理和病理上的作用及影响。发展高效的金属离子检测方法具有重要的意义。本论文基于罗丹明及香豆素为母体设计并合成了四种阳离子检测的荧光探针,用于检测汞离子和铝离子。简述了荧光探针定义,结构以及设计原理,概述了常见的几类阳离子荧光探针的研究进展。利用罗丹明B类衍生物螺内酯胺结构开环导致颜色和光谱特性发生改变的特征,我们设计并合成了以罗丹明B为母体,分别于W醛、2-氯-3-羟基亚甲基-环己-1-烯甲醛、对羟基苯甲醛反应,合成了三种汞离子荧光增强型探针L1、F1、Z1。对其紫外及荧光光谱性质进行了研究,表明这三种探针对Hg2+有较好的选择性和灵敏度,并且分别探究了三种探针与汞离子的作用机理。利用香豆素衍生物含有较多的氮原子能和金属离子发生络合的特性,设计了香豆素为母体的荧光探针J1,通过红外光谱、质谱、1H NMR、13CNMR等手段对该香豆素类荧光化合物进行表征;并对其光谱性质进行了探究,表明该探针对铝离子有较好的选择性和灵敏度,并且分别探究了三种探针与铝离子的作用机理。
[Abstract]:Metal ions participate in various physiological and pathological processes in life system. Metal ions can only be maintained at a certain concentration to ensure normal life activities. In order to better study its physiological and pathological effects and effects. It is of great significance to develop efficient methods for metal ion detection. In this paper, four cationic fluorescent probes were designed and synthesized based on rhodamine and coumarin for the detection of mercury and aluminum ions. In this paper, the definition, structure and design principle of fluorescence probe are briefly introduced, and the research progress of several kinds of cationic fluorescent probes are summarized. Using the structure opening of spironolactone amine, a derivative of rhodamine B, which leads to changes in color and spectral characteristics, we have designed and synthesized rhodamine B as matrix, which was synthesized from 2-chloro-3-hydroxy methylene cyclohexene 1-olefin, respectively. Three kinds of mercury ion fluorescence enhanced probes L _ (1) F _ (1) O _ (1) Z _ (1) were synthesized by the reaction of p-hydroxybenzaldehyde (p-hydroxybenzaldehyde). The UV and fluorescence spectra of these probes were studied. The results showed that the three probes had good selectivity and sensitivity to Hg _ 2, and the interaction mechanism between the three probes and Hg ~ (2 +) was also investigated. Based on the complexation of coumarin derivatives containing more nitrogen, atomic energy and metal ions, a coumarin fluorescence probe J1 was designed. The coumarin fluorescent compound was characterized by IR, MS, 1H NMR13CNMR and so on. The spectral properties of the probe were investigated. The results show that the probe has good selectivity and sensitivity to aluminum ions and the mechanism of the interaction between the three probes and aluminum ions is explored respectively.
【学位授予单位】:南昌大学
【学位级别】:硕士
【学位授予年份】:2017
【分类号】:O657.3

【参考文献】

相关期刊论文 前2条

1 周高;冯锋;陈泽忠;蔡琥;李蓉;郭芳芳;;一种新型香豆素类荧光探针的合成及其对Cu~(2+)的选择性识别[J];分析试验室;2015年06期

2 赵波,周志华;7-羟基-4-甲基香豆素的二阶NLO性质对晶体结构的依赖性[J];南京师大学报(自然科学版);2004年03期



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