多酚类药物与环糊精衍生物的相互作用及其溶液热力学研究
[Abstract]:Disease endangers human health and affects the quality of life. The treatment of diseases has cost a lot of social wealth, so revealing the mechanism of drug efficacy and improving drug efficacy has become a hot topic. Polyphenols are found in some plants and have anti-cancer, anti-inflammatory, obesity treatment and so on. Inclusion of cyclodextrin derivatives can improve the solubility, stability and bioavailability of drugs. The study of solution thermodynamics can reveal the interaction principle of solute molecule and solvent molecule in solution. The study of the interaction between drug molecules and cyclodextrin derivatives and the thermodynamic properties of drug molecules in libido fluid can infer the mechanism of drug molecules acting in vivo and provide a theoretical basis for the development of more effective drugs and new drugs. On the basis of literature investigation, the interaction mechanism between dimethoxy curcumin and cyclodextrin derivatives at different temperatures and pH was studied by phase solubility method, and the method of calorimetry and density was used to study the interaction between dimethoxycurcumin and cyclodextrin derivatives. The thermodynamic properties of drugs in the solution of pseudo life were studied and the interaction mechanism between solute molecules and solvent molecules was discussed. As part of the project funded by the National Natural Science Foundation (NO.21473085), The main components are as follows: part one: the host and guest interactions of dimethoxycurcumin with Ding Ji-尾 cyclodextrin (SBE- 尾 CD),-尾-CD) at different temperatures and pH were studied by phase solubility method. Based on the experimental data, the interaction mechanism between drug molecules and cyclodextrin derivatives was investigated. Part two: the dilute enthalpy and volume properties of protocatechualdehyde in sodium phosphate and potassium buffer solution at different pH. The enthalpy action coefficient and the limit partial molar volume were obtained by fitting the experimental data, the influence of pH on the thermodynamic parameters was analyzed, and the difference of thermodynamics properties of protocatechualdehyde in two different buffers was discussed from the different structures of sodium and potassium ions. Part three: the dilute enthalpy and volume properties of protocatechuic aldehyde and p-hydroxybenzaldehyde in different concentrations of sodium chloride solution. The interaction mechanism between solute molecules and solvent molecules in salt solution from the point of view of solute interaction and solute solvent interaction part 4: dilution enthalpy of protocatechuic aldehyde and p-hydroxybenzaldehyde at different concentrations of potassium chloride. The study of volume properties. The thermodynamic properties of protocatechuic aldehyde and p-hydroxybenzaldehyde caused by the differences in structure of protocatechuic aldehyde and p-hydroxybenzaldehyde are discussed from the point of view of solute interaction and solute solvent interaction. The different thermodynamic properties of sodium chloride and potassium chloride solution were discussed according to the structure of potassium and sodium ions.
【学位授予单位】:聊城大学
【学位级别】:硕士
【学位授予年份】:2017
【分类号】:O636.12;TQ460.1
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