多酚类药物与环糊精衍生物的相互作用及其溶液热力学研究

发布时间：2018-07-24 17:12

【摘要】：疾病危害着人类的健康,影响着人们的生活质量。对于疾病的治疗花费了大量的社会财富,因此揭示药物的药效机理和提高药效成为了研究热点。多酚类药物存在于一些植物中,具有抗癌、消炎、治疗肥胖等作用。环糊精衍生物包合技术能够提高药物的溶解度、稳定性和生物利用度。溶液热力学研究能够揭示溶液中溶质分子和溶剂分子的相互作用原理。研究药物分子与环糊精衍生物的相互作用及药物分子在拟生命体液中的热力学性质,可以推测药物分子在体内发挥疗效的机理,为开发更为有效的药物及新药提供理论依据。本课题在文献调研的基础上,结合实验室实际情况,运用相溶解度法研究了不同温度和pH下双去甲氧基姜黄素与环糊精衍生物的相互作用机制;运用量热法、密度法、研究了药物在拟生命体液中的热力学性质,探讨了溶质分子和溶剂分子的相互作用机理。本论文作为国家自然科学基金资助项目(NO.21473085)的部分工作,主要由以下四部分组成:第一部分:相溶解度法研究了不同温度和pH下双去甲氧基姜黄素与磺丁基-β环糊精(SBE-βCD)、甲基-β环糊精(M-βCD)的主客体相互作用,根据实验数据拟合热力学参数,探讨药物分子与环糊精衍生物分子间相互作用机制。第二部分:原儿茶醛在不同pH磷酸钠、钾缓冲溶液中的稀释焓和体积性质研究。由实验数据拟合得到焓作用系数及极限偏摩尔体积,分析了pH对热力学参数的影响;对原儿茶醛在两种不同缓冲溶液中的热力学性质差别,从钠钾离子的不同结构给予了讨论。第三部分:原儿茶醛和对羟基苯甲醛在不同浓度氯化钠溶液中的稀释焓、体积性质的研究.从溶质-溶质相互作用和溶质-溶剂相互作用角度讨论盐溶液中溶质分子与溶剂分子的相互作用机制第四部分:原儿茶醛和对羟基苯甲醛在不同氯化钾浓度下的稀释焓、体积性质的研究.从溶质-溶质相互作用和溶质-溶剂相互作用角度讨论原儿茶醛和对羟基苯甲醛结构的不同导致的其溶液热力学性质的不同。从钾钠离子结构的不同对氯化钠与氯化钾溶液中的不同热力学性质进行了讨论。
[Abstract]:Disease endangers human health and affects the quality of life. The treatment of diseases has cost a lot of social wealth, so revealing the mechanism of drug efficacy and improving drug efficacy has become a hot topic. Polyphenols are found in some plants and have anti-cancer, anti-inflammatory, obesity treatment and so on. Inclusion of cyclodextrin derivatives can improve the solubility, stability and bioavailability of drugs. The study of solution thermodynamics can reveal the interaction principle of solute molecule and solvent molecule in solution. The study of the interaction between drug molecules and cyclodextrin derivatives and the thermodynamic properties of drug molecules in libido fluid can infer the mechanism of drug molecules acting in vivo and provide a theoretical basis for the development of more effective drugs and new drugs. On the basis of literature investigation, the interaction mechanism between dimethoxy curcumin and cyclodextrin derivatives at different temperatures and pH was studied by phase solubility method, and the method of calorimetry and density was used to study the interaction between dimethoxycurcumin and cyclodextrin derivatives. The thermodynamic properties of drugs in the solution of pseudo life were studied and the interaction mechanism between solute molecules and solvent molecules was discussed. As part of the project funded by the National Natural Science Foundation (NO.21473085), The main components are as follows: part one: the host and guest interactions of dimethoxycurcumin with Ding Ji-尾 cyclodextrin (SBE- 尾 CD),-尾-CD) at different temperatures and pH were studied by phase solubility method. Based on the experimental data, the interaction mechanism between drug molecules and cyclodextrin derivatives was investigated. Part two: the dilute enthalpy and volume properties of protocatechualdehyde in sodium phosphate and potassium buffer solution at different pH. The enthalpy action coefficient and the limit partial molar volume were obtained by fitting the experimental data, the influence of pH on the thermodynamic parameters was analyzed, and the difference of thermodynamics properties of protocatechualdehyde in two different buffers was discussed from the different structures of sodium and potassium ions. Part three: the dilute enthalpy and volume properties of protocatechuic aldehyde and p-hydroxybenzaldehyde in different concentrations of sodium chloride solution. The interaction mechanism between solute molecules and solvent molecules in salt solution from the point of view of solute interaction and solute solvent interaction part 4: dilution enthalpy of protocatechuic aldehyde and p-hydroxybenzaldehyde at different concentrations of potassium chloride. The study of volume properties. The thermodynamic properties of protocatechuic aldehyde and p-hydroxybenzaldehyde caused by the differences in structure of protocatechuic aldehyde and p-hydroxybenzaldehyde are discussed from the point of view of solute interaction and solute solvent interaction. The different thermodynamic properties of sodium chloride and potassium chloride solution were discussed according to the structure of potassium and sodium ions.
【学位授予单位】：聊城大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O636.12;TQ460.1

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