含羧基或磺酸根基团的多足配体金属配合物的合成、结构表征及其性能研究

发布时间：2018-08-13 19:59

【摘要】：自金属配位化合物应用于生活中各个方面以来,配位化合物的结构和性质的研究已成为当今无机化学领域的热点前沿问题。对于金属配位化合物的研究,也随之涉足于各个领域各个方面。本论文在不同有机溶剂中合成了一系列含有羧基或磺酸根基团的多足配体,以钙、镁、锌等原子为活性中心自组装成结构新颖的配合物。同时,利用单晶X-ray衍射仪和光谱分析仪等正确测定其结构。在此基础上,研究了金属离子与不同配体的配位行为、配位特点及其结构的规律性及差异性;通过对其生物活性(抗菌、抗肿瘤)及其催化性质等方面的测试,进一步探讨其潜在的应用价值。本文共合成十种不同的金属配位化合物,并对其性质进行了测试。论文主要分为以下几个部分:1、合成了以N-乙酰-L-苯丙氨酸为主要配体,以4,4’-联吡啶和1,10-菲罗啉分别为辅助配体的两个新型锌的配合物{[Zn(L)_2(4,4’-bipy)]·(H_2O)}n(1)(L=N-乙酰-L-苯丙氨酸)和[Zn(L)_2(phen)·(H_2O)]n(2)(L=N-乙酰-L-苯丙氨酸),并用X-单晶衍射仪、红外光谱仪、元素分析仪对两种配合物的结构进行测试。此外,详细测试了两种新型配合物的生物活性。2、合成了以N-烟酰甘氨酸为配体的新型镉、锰、锌三种原子的配合物{[CdL_2(H_2O)]·(H_2O)_3}n(3)(L=N-烟酰甘氨酸)、[MnL·(H_2O)]n(4)(L=N-烟酰甘氨酸)、[{ZnL(H_2O)_2}·H_2O]n(5)(L=N-烟酰甘氨酸),用X-单晶衍射仪、红外光谱仪、元素分析仪对三种新型配合物进行了表征,并分析了三种物质结构的异同之处。3、合成了以1,4-亚苯基二乙酸为主要配体、2,2’-联吡啶为辅助配体的铜的配位化合物[CuL(bipy)·(H_2O)_5]n(6)(L=4-亚苯基二乙酸),并用X-单晶衍射仪、红外光谱仪、元素分析仪对其结构进行表征,并对其催化三组分偶联反应做了详细的测试,结果表明,配合物6对该反应具有较高的催化性能。4、合成了以4-甲酰基-1,3-苯二磺酸钠缩2-糠酸酰肼、4-甲酰基-1,3-苯二磺酸钠缩烟酰肼为配体的新型两种钙的配位化合物{[CaL·(H_2O)4]·(H_2O)4}n(7)(L=4-甲酰基-1,3-苯二磺酸钠缩2-糠酸酰肼)、[CaL·(H_2O)_5]n(8)(L=4-甲酰基-1,3-苯二磺酸钠缩烟酰肼);以4-氨基-3-甲基苯磺酸与镁的新型配位化合物[Mg·(H_2O)6]·L_2(9)(L=4-氨基-3-甲基苯甲酸);以2-甲苯磺酸钠缩2-糠酸酰肼为配体的新型钙的配位化合物{[CaL_2·(H_2O)_2·2H_2O]}n(10)(L=2-甲苯磺酸钠缩2-糠酸酰肼),并用X-单晶衍射仪、红外光谱仪、元素分析仪对其结构进行了表征。
[Abstract]:Since the application of metal coordination compounds in various aspects of life, the study of the structure and properties of coordination compounds has become a hot topic in the field of inorganic chemistry. The study of metal coordination compounds also involved in various fields. In this paper, a series of polypodal ligands containing carboxyl or sulfonic groups were synthesized in different organic solvents, and self-assembled with calcium, magnesium and zinc atoms as active centers to form novel complexes. At the same time, the structure was determined by single crystal X-ray diffractometer and spectrometer. On this basis, the coordination behavior, coordination characteristics, structural regularity and difference of metal ions with different ligands were studied, and their biological activities (antimicrobial, anti-tumor) and their catalytic properties were tested. Further explore its potential application value. Ten different metal coordination compounds were synthesized and their properties were tested. This paper is divided into the following parts: 1. The main ligand of N-acetyl-L-phenylalanine was synthesized. Two new zinc complexes {[Zn (L) _ 2 (4H _ 2O _ 4)] (H _ 2O)} (H _ 2O)} n (1) (Zn (L) _ 2-acetyl-L-phenylalanine) and [Zn (L) _ 2 (phen) (H _ 2O)] n (2) (Lnacetyl-L-phenylalanine) were used as auxiliary ligands, respectively. The structure of the two complexes was tested by elemental analyzer. In addition, the biological activity of two new complexes was tested in detail, and the complexes {[CdL_2 (H2O)] (H2O) 3} n (LN- nicotinyl glycine), [MnL (H2O)] n (4) (LN- nicotinyl glycine), [{ZnL (H2O) 2} H2O] n (5) (LN- nicotinyl glycine) were synthesized by the synthesis of the complexes {[CdL_2 (H2O)] (H2O) (H2O) 3} n (LN- nicotinyl glycine), [{ZnL (H2O) 2} H2O] n (5) (LN- nicotinyl glycine), and [ZnL (H2O) 2} H2O] n (5) (LN- nicotinyl glycine). The three new complexes were characterized by infrared spectrometer and elemental analyzer. In this paper, the similarities and differences of three compounds were analyzed, and the coordination compound [CuL (bipy) (H2O] 5] n (6) (Ln 4phenylene diacetic acid) was synthesized with 1h4phenylene diacetic acid as the main ligands, [CuL (bipy) (H2O] 5] n (Ln 4- phenylenediacetic acid), and was characterized by X-ray single crystal diffractometer and infrared spectrometer. Its structure was characterized by elemental analyzer, and its catalytic three-component coupling reaction was tested in detail. Complex 6 has high catalytic activity for this reaction. A new calcium coordination compound {[CaL (H2O) 4] (H2O) 4} n (7) (Ln 4- formyl) n (7) (Ln 4- formylformyl) n (7) was synthesized with sodium 4-furanoyl hydrazide (2-furoic acid) 4-formylhydrazide as ligand, and the coordination compound {[CaL (H2O) 4] (H2O) 4} n (Ln 4- formyl) was synthesized by using complex 6 as the ligand of this reaction. The coordination compound {[CaL (H2O) 4] (H2O) 4} n (Ln 4- formyl) was synthesized. [CaL (H2O) 5] n (8) (L4 formyl-1-3-benzenesulfonate sodium nicotinyl hydrazide); a new coordination compound of magnesium with 4-amino-3-methyl benzenesulfonic acid [mg (hs) 2O 6] L 2 (9) (Ln (H2O) 5] n (8); sodium 2- toluenesulfonate 2-furanyl acid A new calcium coordination compound {[CaL_2 (H _ S _ 2O) _ 2 2H_2O]} _ n (10) (sodium Ln _ 2-toluenesulfonate _ 2-furoic acid hydrazide) with hydrazine as ligand was used by X-ray diffraction. Its structure was characterized by infrared spectrometer and elemental analyzer.
【学位授予单位】：青海师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O641.4

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