功能化胆碱离子液体—聚合物双水相及其对某些植物化学品的萃取分离性能
发布时间：2018-08-22 07:10
【摘要】：与传统双水相相比,离子液体双水相具有分相快、粘度低、几乎无乳化现象等优点,在萃取分离领域得到了广泛的关注。随着对离子液体研究的逐渐深入,人们发现,在传统的离子液体-无机盐双水相体系中,咪唑类/吡啶类离子液体的生物/环境毒性和高浓度无机盐废水的产生,在一定程度上限制了它们的可持续应用。解决这些问题的关键是发展环境友好的离子液体双水相体系。可生物降解的胆碱离子液体可以参与形成环境友好的离子液体双水相,但是胆碱类离子液体的结构相对简单,能够与它们形成双水相的成相物质很少。作为国家自然科学基金资助课题(No.21133009)研究工作的一部分本文从环境友好的乙二醇衍生物出发,设计、合成了一系列具有胆碱结构的离子液体。在此基础上,系统研究了这些离子液体与热响应聚合物EOPO形成双水相的相平衡性质及其对绿原酸、咖啡酸等植物化学品的选择性分离,主要研究内容包括:1.设计、合成了24种功能化胆碱离子液体,使用核磁共振光谱(~1H NMR,13C NMR)、差示扫描量热(DSC)和热重分析(TGA)等技术对这些离子液体进行表征。结果表明,这些离子液体具有优良的低温性能及良好的热稳定性,属于室温离子液体的范畴。2.测定了本文所合成的功能化胆碱离子液体与EOPO 1900,EOPO2000,EOPO2700和EOPO5800等热响应聚合物形成双水相体系的液-液平衡数据,构建了功能化胆碱离子液体-聚合物双水相体系的液-液平衡相图,系统研究了离子液体和聚合物的结构,体系的温度等因素对离子液体双水相相平衡的影响,深入分析了这类双水相体系的成相规律。3.研究了绿原酸和咖啡酸在功能化胆碱离子液体-聚合物双水相体系中的分配行为,系统讨论了双水相组成、绿原酸和咖啡酸的分子结构等因素对它们分配性能的影响,建立了基于离子液体-聚合物双水相体系的绿原酸和咖啡酸绿色分离方法。研究结果表明,在优化的条件下,通过一步萃取,这类双水相体系对绿原酸和咖啡酸的萃取率最高可分别达到97.0%和96.7%。4.研究了功能化胆碱离子液体-聚合物双水相体系对绿原酸和咖啡因的选择性分离性能,分析了相组分的浓度、聚合物的结构、体系的温度等因素对选择性分离性能的影响,提出了一种基于环境友好离子液体双水相体系的绿原酸和咖啡因的选择性分离方法。在优化条件下,通过一步萃取,绿原酸和咖啡因在双水相体系中的选择性分离系数最高可以达到195。
[Abstract]:Compared with traditional aqueous two-phase, ionic liquid aqueous two-phase has many advantages, such as fast phase separation, low viscosity, almost no emulsification and so on, and has been widely concerned in the field of extraction and separation. With the further study of ionic liquids, it has been found that in the traditional ionic liquid-inorganic salt aqueous two-phase system, the biological / environmental toxicity of imidazole / pyridine ionic liquids and the production of high concentration inorganic salt wastewater are observed. To some extent, it limits their sustainable application. The key to solve these problems is to develop environmental friendly ionic liquid aqueous two-phase system. Biodegradable choline ionic liquids can participate in the formation of environment-friendly aqueous ionic liquids, but the structure of choline ionic liquids is relatively simple. As part of the research work supported by National Natural Science Foundation (No.21133009), a series of ionic liquids with choline structure were designed and synthesized from the environmentally friendly ethylene glycol derivatives. On this basis, the phase equilibrium properties of these ionic liquids and thermally responsive polymer EOPO to form aqueous two-phase and their selective separation for plant chemicals such as Lv Yuan acid and caffeic acid were systematically studied. The main research contents include: 1. Twenty-four functional choline ionic liquids were designed and synthesized and characterized by 1H NMR-13C NMR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The results show that these ionic liquids have excellent low temperature properties and good thermal stability, which belong to the category of room temperature ionic liquids. The liquid-liquid equilibrium data of the functionalized choline ionic liquid synthesized in this paper and the thermo-responsive polymers such as EOPO 1900 and EOPO2700 and EOPO5800 were measured, and the liquid-liquid equilibrium diagram of the functionalized choline ion liquid-polymer aqueous two-phase system was constructed. The effects of the structure of ionic liquid and polymer and the temperature of the system on the phase equilibrium of aqueous two-phase ionic liquid were systematically studied. The phase formation law of this kind of aqueous two-phase system was analyzed in depth. The partition behavior of Lv Yuan acid and caffeic acid in functionalized choline ionic liquid-polymer aqueous two-phase system was studied. The effects of the composition of aqueous two-phase and the molecular structure of Lv Yuan acid and caffeic acid on their partition properties were discussed systematically. A green separation method for Lv Yuan acid and caffeic acid was established based on ionic liquid-polymer aqueous two-phase system. The results show that under the optimized conditions, the extraction rates of Lv Yuan acid and caffeic acid can be up to 97.0% and 96.70..4 respectively by one-step extraction of this two-phase aqueous system. The selective separation of Lv Yuan acid and caffeine by functionalized choline ionic liquid-polymer aqueous two-phase system was studied. The effects of phase concentration, polymer structure and system temperature on the selective separation performance were analyzed. A selective separation method of Lv Yuan acid and caffeine based on environmental friendly ionic liquid aqueous two-phase system was proposed. Under the optimized conditions, the highest selective separation coefficients of Lv Yuan acid and caffeine in aqueous two-phase system can be obtained by one-step extraction.
【学位授予单位】：河南师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O658.2
本文编号：2196338
[Abstract]:Compared with traditional aqueous two-phase, ionic liquid aqueous two-phase has many advantages, such as fast phase separation, low viscosity, almost no emulsification and so on, and has been widely concerned in the field of extraction and separation. With the further study of ionic liquids, it has been found that in the traditional ionic liquid-inorganic salt aqueous two-phase system, the biological / environmental toxicity of imidazole / pyridine ionic liquids and the production of high concentration inorganic salt wastewater are observed. To some extent, it limits their sustainable application. The key to solve these problems is to develop environmental friendly ionic liquid aqueous two-phase system. Biodegradable choline ionic liquids can participate in the formation of environment-friendly aqueous ionic liquids, but the structure of choline ionic liquids is relatively simple. As part of the research work supported by National Natural Science Foundation (No.21133009), a series of ionic liquids with choline structure were designed and synthesized from the environmentally friendly ethylene glycol derivatives. On this basis, the phase equilibrium properties of these ionic liquids and thermally responsive polymer EOPO to form aqueous two-phase and their selective separation for plant chemicals such as Lv Yuan acid and caffeic acid were systematically studied. The main research contents include: 1. Twenty-four functional choline ionic liquids were designed and synthesized and characterized by 1H NMR-13C NMR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The results show that these ionic liquids have excellent low temperature properties and good thermal stability, which belong to the category of room temperature ionic liquids. The liquid-liquid equilibrium data of the functionalized choline ionic liquid synthesized in this paper and the thermo-responsive polymers such as EOPO 1900 and EOPO2700 and EOPO5800 were measured, and the liquid-liquid equilibrium diagram of the functionalized choline ion liquid-polymer aqueous two-phase system was constructed. The effects of the structure of ionic liquid and polymer and the temperature of the system on the phase equilibrium of aqueous two-phase ionic liquid were systematically studied. The phase formation law of this kind of aqueous two-phase system was analyzed in depth. The partition behavior of Lv Yuan acid and caffeic acid in functionalized choline ionic liquid-polymer aqueous two-phase system was studied. The effects of the composition of aqueous two-phase and the molecular structure of Lv Yuan acid and caffeic acid on their partition properties were discussed systematically. A green separation method for Lv Yuan acid and caffeic acid was established based on ionic liquid-polymer aqueous two-phase system. The results show that under the optimized conditions, the extraction rates of Lv Yuan acid and caffeic acid can be up to 97.0% and 96.70..4 respectively by one-step extraction of this two-phase aqueous system. The selective separation of Lv Yuan acid and caffeine by functionalized choline ionic liquid-polymer aqueous two-phase system was studied. The effects of phase concentration, polymer structure and system temperature on the selective separation performance were analyzed. A selective separation method of Lv Yuan acid and caffeine based on environmental friendly ionic liquid aqueous two-phase system was proposed. Under the optimized conditions, the highest selective separation coefficients of Lv Yuan acid and caffeine in aqueous two-phase system can be obtained by one-step extraction.
【学位授予单位】：河南师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O658.2
【参考文献】
相关期刊论文 前10条
1 朱攀攀;马亚琴;窦华亭;韩智;李申;;超声局部效应对咖啡酸稳定性及抗氧化性的影响[J];食品科学;2015年23期
2 李桂珍;唐为扬;曹伟敏;王倩;朱涛;;印迹分子聚合物结合低共熔溶剂用于山楂中咖啡酸的固相萃取（英文）[J];色谱;2015年08期
3 彭贵龙;周光明;秦红英;陈军华;;非离子表面活性剂-超声辅助萃取-高效液相色谱同时定金银花中绿原酸和咖啡酸的含量[J];中华中医药学刊;2014年08期
4 王新红;李雪梅;蔡晨;戴兢陶;文福姬;王京平;;离子液体提取山楂绿原酸的工艺优化[J];农业工程学报;2014年10期
5 李继睿;禹练英;杨孝辉;郭君;;超临界流体萃取野菊花中绿原酸工艺研究[J];食品研究与开发;2012年09期
6 Martin Tongai Mazvimba;于颖;崔志芹;张莹;;从干烟草叶中超声波辅助提取绿原酸的正交设计及优化(英文)[J];中国天然药物;2012年04期
7 邵礼梅;陈立柱;许世伟;李延雪;;HPLC法同时测定蒲公英中绿原酸和咖啡酸的含量[J];中国药事;2012年01期
8 李琴;;从茶叶中绿色提取咖啡因的方法探讨[J];湖北林业科技;2011年04期
9 李江;;高效液相色谱法测定忍冬藤不同采收期中绿原酸和咖啡酸的含量[J];中国医药导报;2010年32期
10 ;Study on Extraction and Purification Technology of Chlorogenic acid from Lonicera japonica Thunb.[J];Medicinal Plant;2010年07期
相关硕士学位论文 前3条
1 代丽丽;乳酸离子液体及其水溶液物理化学性质研究[D];辽宁大学;2012年
2 李志勇;离子液体双水相对某些生物分子的萃取分离性能研究[D];河南师范大学;2010年
3 辜鹏;无机盐/低分子有机物双水相体系的研究及其应用[D];湘潭大学;2008年
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