聚乳酸的改性及其在缓释药物体系中的应用研究
[Abstract]:Polylactic acid (Polylactic) has good biodegradability, biocompatibility, good mechanical properties and processability. It is one of the most important materials in the field of biodegradable medical materials, and has important application value in slow-release drug system. However, the hydrophobic group on the surface of polylactic acid makes its hydrophilicity lower, leading to the decrease of the cell compatibility, which is not conducive to the absorption of the drug by the cell and thus reduces its efficacy. In order to improve the performance defects of polylactic acid, improve its hydrophilicity and degradation performance, and increase the performance of polylactic acid in slow-release drug system, the polylactic acid microspheres were prepared with modified PLA as capsule material in this paper. The release properties of poly (lactic acid) loaded microspheres were studied. (1) Polylactic acid (EPLA).) modified by hexanediamine was prepared by acylation of poly (lactic acid) with phosphorous pentachloride (PCl5) as acylated reagent and then reaction with hexanediamine. The structure of the product was characterized by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). It was proved that hexane diamine was grafted onto polylactic acid. (2) Hexanediamine modified polylactic acid (EPLA) was used as raw material. Collagen modified polylactic acid was obtained by first reacting with glutaraldehyde and then with collagen. The modified poly (lactic acid) was characterized by FTIR and fluorescein isothiocyanate labeling. The results showed that glutaraldehyde and collagen were successfully grafted onto the polylactic acid modified by hexanediamine. The graft rate of collagen in modified PLA was 8.7%. (3) the properties of the modified PLA were determined. The results showed that the hydrophilicity of poly (lactic acid) modified by collagen glutaraldehyde and hexanediamine was the best and that of hexanediamine was the second while the hydrophilicity of PLA was the worst. The degradation performance of the material was investigated from the aspects of the weight loss rate and pH change of the degradation medium. The results showed that in the early stage of degradation, the weight loss rate of modified PLA was higher than that of PLA after degradation. In the process of degradation, the pH of the degradation medium of unmodified polylactic acid decreased obviously, while the pH of the degradation medium of EPLA and CPLA also decreased, but the decrease was relatively small. (4) the collagen modified polylactic acid was used as the capsule material. Polylactic acid microspheres modified by trypsin were prepared by water in oil in water (W1/O/W2) solvent volatilization method with trypsin as core material. The optimum technological conditions were obtained as follows: the mass ratio of water-oil ratio 1: 6 CPLA to trypsin was 1: 6, the mixing rate of colostrum was 14000 r / min, the concentration of polyvinyl alcohol was 0.75%, the mixing rate of composite emulsion was 800 r / min, and the concentration of polylactic acid was 5.0%. The morphology of the drug-loaded microspheres was characterized by environmental scanning electron microscope. The results showed that the drug-loaded microspheres had a good effect of forming, the surface was smooth, the morphology was round, the dispersity was good, and the size of the microspheres was uniform. The average particle size of the drug-loaded microspheres prepared under the optimum conditions was 2.75 渭 m EPLA-loaded microspheres, 4.22 渭 m CPLA microspheres and 4.09 渭 m CPLA microspheres. The encapsulation efficiency and drug loading capacity of three kinds of drug-loaded microspheres were determined. The results were as follows: CPLA (29) EPLA (29) PLA. The in vitro release properties of trypsin loaded microspheres were studied. The results showed that PLA microspheres and CPLA loaded microspheres had better long-term sustained release effects than those of PLA loaded microspheres.
【学位授予单位】:齐鲁工业大学
【学位级别】:硕士
【学位授予年份】:2016
【分类号】:O633.14;TQ460.1
【相似文献】
相关期刊论文 前10条
1 韩敏;苏秀霞;李仲谨;;载药微球制剂的研究进展[J];应用化工;2007年05期
2 崔嘉扬;乐黄莺;沈振陆;;基于树枝状嵌段共聚物的载药微球的制备及其药物释放表征[J];上海交通大学学报(农业科学版);2012年06期
3 李航;袁华;仲谦;任杰;;5-氟尿嘧啶载药微球的制备工艺及性能研究[J];功能材料;2007年02期
4 章莉娟;钱宇;潘吉铮;;聚合物载药微球活性组分控释性能的动力学模拟[J];化工学报;2006年08期
5 李峻峰;张利;李钧甫;邹琴;杨维虎;李玉宝;;香草醛交联壳聚糖载药微球的性能及其成球机理分析[J];高等学校化学学报;2008年09期
6 张琳琳;涂姜磊;徐静;程莉萍;张志斌;陈世龙;;壳聚糖-海藻酸钠载药微球的缓释性能研究[J];材料导报;2010年24期
7 李春生,寿崇琦,左志俊;载药微球释放规律的实验研究[J];化学研究与应用;1999年03期
8 张爱英,李杰,冯增国,张勇;生物可降解聚乙二醇-b-聚对苯二甲酸丁二醇酯共聚物载药微球的制备[J];应用化学;2003年03期
9 尚红梅;李引乾;曹新宇;陈辉玲;董玲玲;童德文;马永梅;;SiO_2载药微球的研究及应用[J];材料导报;2012年S1期
10 杨黎燕;李仲谨;尤静;张静姝;;淀粉基交联共聚载药微球的制备及其生物性能研究[J];应用化工;2011年10期
相关会议论文 前5条
1 王彦卿;张朝平;;磁性明胶载药微球的制备及体外释药研究[A];第五届中国功能材料及其应用学术会议论文集Ⅱ[C];2004年
2 马桂蕾;宋存先;韩锐;付招娣;;带有微孔结构紫杉醇微球制备及其在小鼠体内抗肿瘤活性研究[A];天津市生物医学工程学会2006年学术年会论文摘要集[C];2006年
3 刘艳飞;黄可龙;彭东明;刘素琴;吴弘;;聚碳酸亚丙酯马来酸酐酯的合成及其载药微球的制备[A];第十届中国科协年会论文集(三)[C];2008年
4 刘艳飞;黄可龙;彭东明;刘素琴;吴弘;;聚碳酸亚丙酯马来酸酐酯的合成及其载药微球的制备[A];第十届中国科协年会第18分会二氧化碳减排和绿色化利用与发展研讨会论文集[C];2008年
5 简永增;王耀先;程树军;;聚酸酐载药微球的制备[A];2005年全国高分子学术论文报告会论文摘要集[C];2005年
相关博士学位论文 前1条
1 李近;可生物降解载药微球的制备和释药动力学的研究[D];清华大学;2008年
相关硕士学位论文 前10条
1 童欣;5-Fu/GoFe_2O_4/PCL磁性载药微球的制备及其表征[D];大连海事大学;2015年
2 王敬龙;多层载药微球型骨修复材料的制备及其对HPMSCs生物学活性影响的研究[D];吉林大学;2016年
3 陆海玲;磁性荧光聚合物载药微球的制备及应用[D];广东药科大学;2016年
4 王秋艳;基于氧化海藻酸钠载药微球的制备与研究[D];华南理工大学;2016年
5 张竹;结肠靶向纳米载药微球的制备及其体外释药行为研究[D];重庆大学;2016年
6 崔苗苗;聚乳酸的改性及其在缓释药物体系中的应用研究[D];齐鲁工业大学;2016年
7 吴海燕;丝素载药微球的制备及其性能研究[D];苏州大学;2008年
8 孙爱平;喷雾干燥法制备聚乳酸载药微球及其药物释放行为研究[D];天津大学;2008年
9 赵天倚;聚乳酸包覆次血红素六肽微球的制备及初步活性研究[D];吉林大学;2011年
10 康世胤;复合功能载药微球的制备及在脊髓损伤治疗中的应用初探[D];天津大学;2011年
,本文编号:2198938
本文链接:https://www.wllwen.com/kejilunwen/huaxue/2198938.html