近红外光谱用于中药定量分析的技术规范化研究进展

发布时间：2018-09-03 18:45

【摘要】：近红外(near-infrared,NIR)光谱技术在中药行业引起了日益广泛的关注,但目前该项技术仍处于研究阶段,缺乏统一的标准及规范,将其应用于中药质量控制及中药制药过程分析,尚需解决NIR光谱分析技术的适用范围问题、建模样品的代表性及模型的可扩展性问题、光谱采集条件的优化问题、异常光谱的剔除原则问题、模型的评价方法问题、模型的更新及转移方法问题等。只有这些关键问题获得解决,并经过方法学验证,形成规范,才能充分发挥NIR光谱技术的优势,应用于中药质量控制和制药过程监测。该文将对NIR光谱技术在中药和其他领域的研究报道中提出的方法进行总结和比较,提出中药NIR光谱的技术规范化研究方法和思路,以促进NIR光谱技术的规范化应用。
[Abstract]:Near infrared (near-infrared,NIR) spectroscopy has attracted more and more attention in traditional Chinese medicine (TCM) industry. However, it is still in the research stage and lacks of uniform standards and specifications. It is applied to the quality control and pharmaceutical process analysis of TCM. The application scope of NIR spectrum analysis technology, the representativeness of modeling samples and the expansibility of the model, the optimization of spectral acquisition conditions, the elimination principle of abnormal spectra, the evaluation methods of models, and so on, are still to be solved. The updating and transferring methods of the model, etc. Only when these key problems are solved and validated by methodology, can the advantages of NIR spectrum technology be brought into full play and applied to quality control and pharmaceutical process monitoring of traditional Chinese medicine. This paper summarizes and compares the methods proposed in the research reports of NIR spectroscopy in traditional Chinese medicine and other fields, and puts forward the technical standardization research methods and ideas of NIR spectrum of traditional Chinese medicine, in order to promote the standardized application of NIR spectrum technology.
【作者单位】：浙江大学药物信息学研究所;
【基金】：国家“重大新药创制”科技重大专项(2014ZX09201022-009)
【分类号】：R284;O657.33

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