阿司匹林表面分子印迹聚合物的制备及其缓释性能评价

发布时间：2018-10-11 18:46

【摘要】：分子印迹聚合物微球作为一种功能性高分子材料,已经被广泛应用于药物的检测、分离以及缓释等领域。本文以阿司匹林(Asp)为模板分子,活化修饰的硅胶为载体,丙烯酰胺(AM)为功能单体,乙二醇二甲基丙烯酸酯(EGDMA)为交联剂通过沉淀法制备了表面分子印迹微球,并对其的药物缓释性能进行了研究。吸附实验表明聚合物的吸附性能良好;热重实验表明聚合物的热稳定性良好;体外释放实验表明聚合物具有药物缓释能力。为进一步赋予分子印迹微球更多的功能性,阿司匹林作为模板分子,甲基丙烯酸(MAA)为功能单体,3-羟甲基丙烷三甲基丙烯酸酯(TRIM)为交联剂,通过回流沉淀法制备了分子印迹内核;同时,利用印迹内核表面多余的烯基通过与亲水单体丙烯酰胺(AM)发生自由基聚合反应,进行了亲水壳的枝接并对其亲水性能进行了表征。吸附实验表明聚合物可以在近水相表现出良好的吸附性能;并且亲水层能够增大聚合物的吸附量。
[Abstract]:As a functional polymer material, molecularly imprinted polymer microspheres have been widely used in drug detection, separation and sustained release. In this paper, surface molecularly imprinted microspheres were prepared by precipitation method using aspirin (Asp) as template molecule, activated modified silica gel as carrier, acrylamide (AM) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent. The drug release properties were studied. Adsorption experiments show that the polymer has good adsorption performance, thermogravimetric test shows that the thermal stability of the polymer is good, and the in vitro release test shows that the polymer has drug release ability. In order to further enhance the functionality of molecularly imprinted microspheres, molecular imprinting kernels were prepared by refluxing precipitation method using aspirin as template molecule, (MAA) as functional monomer and (TRIM) as crosslinking agent. At the same time, the hydrophilic shell was grafted by free radical polymerization with hydrophilic monomer acrylamide (AM), and its hydrophilicity was characterized by using the excess enyl group on the surface of imprinted core. The adsorption experiments show that the polymer can exhibit good adsorption performance in the near aqueous phase and the hydrophilic layer can increase the adsorption capacity of the polymer.
【学位授予单位】：天津工业大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O631.3;TQ460.1

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