氮杂环卡宾催化有机反应的研究进展
发布时间：2018-10-29 12:29
【摘要】：自从1991年Arduengo第一次分离得到稳定的游离N-杂环卡宾以来,其作为一种高效的有机催化剂得到了迅速的发展.由于N-杂环卡宾的极性反转特性,它在有机合成中构建复杂分子的地位举足轻重.一些特定的路易斯碱及氧化剂可诱导卡宾与羰基化合物形成Breslow中间体、烯醇化合物和高烯醇化合物,这些中间体极大地拓展了卡宾的应用范围.综述了近几年N-杂环卡宾在催化有机反应中的研究进展,如催化安息香缩合反应、Stetter反应、a~3-d~3极性反转反应、环合反应和氟化反应等.
[Abstract]:Since 1991, when Arduengo was separated for the first time to obtain stable free N-heterocyclic carbene, it has been developed rapidly as an efficient organic catalyst. N- heterocyclic carbene plays an important role in the construction of complex molecules in organic synthesis due to its polar reversal characteristics. Some specific Lewis bases and oxidants can induce carbene and carbonyl compounds to form Breslow intermediates, enol compounds and high enol compounds. These intermediates greatly expand the application of carbene. The research progress of N-heterocyclic carbene in catalytic organic reactions such as catalytic benzoin condensation, Stetter reaction, a~3-d~3 polarity reversal reaction, cyclization reaction and fluorination reaction were reviewed.
【作者单位】： 中国药科大学天然药物活性物质与功能国家重点实验室;中国科学院上海药物研究所受体结构与功能重点实验室;
【基金】：国家自然科学基金(No.21632008)资助项目~~
【分类号】：O621.251
[Abstract]:Since 1991, when Arduengo was separated for the first time to obtain stable free N-heterocyclic carbene, it has been developed rapidly as an efficient organic catalyst. N- heterocyclic carbene plays an important role in the construction of complex molecules in organic synthesis due to its polar reversal characteristics. Some specific Lewis bases and oxidants can induce carbene and carbonyl compounds to form Breslow intermediates, enol compounds and high enol compounds. These intermediates greatly expand the application of carbene. The research progress of N-heterocyclic carbene in catalytic organic reactions such as catalytic benzoin condensation, Stetter reaction, a~3-d~3 polarity reversal reaction, cyclization reaction and fluorination reaction were reviewed.
【作者单位】： 中国药科大学天然药物活性物质与功能国家重点实验室;中国科学院上海药物研究所受体结构与功能重点实验室;
【基金】：国家自然科学基金(No.21632008)资助项目~~
【分类号】：O621.251
【相似文献】
相关期刊论文 前10条
1 蒋锡夔;;卡宾的化学[J];化学通报;1962年07期
2 蒋锡夔;;卡宾化学的进展及某些问题[J];科学通报;1965年08期
3 张必良;;卡宾化学分支——高张力环卡宾的进展[J];化学通报;1987年11期
4 马艳凤,马楠,孟繁友;关于卡宾的研究[J];松辽学刊(自然科学版);1997年03期
5 孙小宇;吴R，
本文编号：2297698
本文链接：https://www.wllwen.com/kejilunwen/huaxue/2297698.html
教材专著
