静电自组装壳聚糖载药空心微胶囊的制备及释放性能

发布时间：2018-11-11 21:46

【摘要】：采用目前材料领域新型的自组装模板法制备了壳聚糖空心微胶囊。首先使用分散聚合的方法合成了粒径均一的聚苯乙烯微球,粒径范围在1~2μm。然后用H2SO4将聚苯乙烯表面功能化为磺化聚苯乙烯,并以之为模板,将壳聚糖静电组装于其表面,经戊二醛交联后用四氢呋喃溶解模板,成功制备出生物相容和可降解的交联壳聚糖空心微胶囊。研究采用凝胶渗透色谱和纳米粒度仪测试合成聚苯乙烯微球的分子量、粒径及粒度分布等性能;利用Zeta电位仪、扫描电镜、透射电镜和热重分析仪对核-壳结构与空心微胶囊的特性进行表征。以吡虫啉为模型药物,通过吸附与渗透的方式负载到壳聚糖交联空心微胶囊,在甲醇下进行缓释实验。傅里叶转换红外光谱仪的表征证明氢键力在壳聚糖对吡虫啉的负载起到了重要作用。释放实验的结果表明,壳聚糖空心微胶囊对吡虫啉的载药量达到31.78%,前期出现的释放量达56.63%,释放实验后期能保持一定的缓慢释放量,表明壳聚糖空心微胶囊的载药部位主要在其表面与内部,而进入微胶囊内部的药物则需要在交联壳聚糖降解后缓慢释出,达到所期望的缓释效果。
[Abstract]:Chitosan hollow microcapsules were prepared by a new self-assembly template method in the field of materials. At first, the homogeneous polystyrene microspheres were synthesized by dispersion polymerization. The particle size ranges from 1 渭 m to 2 渭 m. Then the surface function of polystyrene was transformed into sulfonated polystyrene by H2SO4. Chitosan was electrostatic assembled on the surface of polystyrene. The template was dissolved by tetrahydrofuran after crosslinking with glutaraldehyde. The biocompatible and degradable chitosan hollow microcapsules were successfully prepared. The molecular weight, particle size and particle size distribution of synthesized polystyrene microspheres were measured by gel permeation chromatography and nano-particle size analyzer. The characteristics of core-shell structure and hollow microcapsules were characterized by Zeta potentiometer, scanning electron microscope, transmission electron microscope and thermogravimetric analysis. Imidacloprid was used as the model drug. The chitosan crosslinked hollow microcapsules were loaded with imidacloprid by adsorption and osmosis, and sustained release experiments were carried out under methanol. The characterization of FTIR proved that hydrogen bond force plays an important role in the loading of imidacloprid by chitosan. The results of release experiment showed that the amount of imidacloprid loaded by chitosan hollow microcapsule reached 31.78%, and the release amount reached 56.63% in the early stage, and the slow release amount was maintained in the later stage of release experiment. The results showed that the drug delivery site of chitosan hollow microcapsules was mainly on its surface and interior, while the drugs entering the microcapsules needed to be released slowly after the degradation of cross-linked chitosan, and the desired sustained release effect was achieved.
【作者单位】：西南科技大学材料科学与工程学院生物质材料教育部工程研究中心;
【基金】：国家核设施退役及放射性废物治理科研重点项目2014(806)(14ZG6101) 青海省科技计划(N2014-GX-Q04) 西南科技大学生物质材料(教育部)工程中心平台基金项目(14tdsc01)
【分类号】：O636.1;TQ450.1

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