郁金块根的化学成分研究

发布时间：2018-11-15 06:46

【摘要】：姜黄属(Curcuma)隶属于姜科(Zingiberaceae),全世界约有60余种,我国产16种,主要分布于我国东南南部至西南部地区。其主要化学成分为萜类和二苯庚烷类化合物。姜黄属中有许多植物可作为中药材使用,郁金(Curcuma aromatica Salisb.)便是其中之一。据《药性论》记载,郁金块根具有较好的行气破血、消积止痛的作用,是临床上常用的活血化瘀药物,主要用于治疗血气心痛、脘腹胀痛、饮食积滞、痛经、血滞经闭、跌打损伤。为进一步深入研究郁金中的活性成分,本论文综合采用多种色谱分离技术,对郁金块根的75%乙醇提取物进行了系统的化学成分研究,结合光谱学等结构鉴定技术,从中共分离并鉴定了 43个化合物,包括24个倍半萜类(1-8,11-26),4个二萜类(9-10,27-28),11个二苯庚烷类(29-34,37-41),2个酚类化合物(35-36),以及2个甾醇类(42、43)化合物。其中,化合物1为具有全新骨架的倍半萜类化合物,29和30为首次从姜黄属中发现的二苯庚烷二聚体类化合物,2-8为新的倍半萜类化合物,9-10为新的二萜类化合物,31-34为新的二苯庚烷类化合物,35和36为新的酚类化合物。活性研究表明:化合物 1,2,5-8,11-12,14,16,18-19,29-31,33,37-38,40-41 具有良好的抑制 H2O2 引起的 PC12细胞损伤的作用(P0.001)。本研究为该植物的深入开发提供了前期研究基础。此外,本论文对姜黄属的化学成分研究进展进行了综述。
[Abstract]:There are more than 60 species of turmeric in the world belonging to (Zingiberaceae), of the family Curcumae, 16 of which are made in China, mainly from the south to the southwest of southeast China. The main chemical constituents are terpenoids and diphenylheptane compounds. There are many plants in turmeric that can be used as traditional Chinese medicine, (Curcuma aromatica Salisb.). Is one of them. According to the "theory of medicine", the root of Tujin has a good effect of removing qi and breaking blood and relieving pain. It is a commonly used medicine for promoting blood circulation and removing blood stasis. It is mainly used to treat blood gas, abdominal distending pain, food accumulation stagnation, dysmenorrhea, blood stagnation and amenorrhea, which is mainly used in the treatment of blood qi, abdominal distention pain, food stagnation, dysmenorrhea, and blood stagnation. A falling injury. In order to further study the active components in tuber, the chemical constituents of 75% ethanol extract from tuber were studied by using a variety of chromatographic separation techniques, and the structural identification techniques such as spectroscopy were used. A total of 43 compounds were isolated and identified, including 24 sesquiterpenoids (1-81-26), 4 diterpenoids (9-1047-28), 11 diphenylheptane (29-34h37-41), and 2 phenolic compounds (35-36). And two sterols (42o43) compounds. Among them, compounds 1 are sesquiterpenoids with a new skeleton, 29 and 30 are diphenylheptane dimers, 2-8 are new sesquiterpenes, 9-10 are new diterpenoids, 31-34 are new diphenyl heptane compounds, 35 and 36 are new phenolic compounds. The activity study showed that compound 1: 1, 2, 2, 2, 5, 8, 11, 12, 14, 1, 16, 18, 1929, 31, 3, 3, 3, 3, 37, 38, 38, 40-41, had a good inhibitory effect on PC12 cell damage induced by H2O2 (P0. 001). This study provides a basis for the further development of this plant. In addition, the chemical constituents of Curcuma were reviewed in this paper.
【学位授予单位】：昆明理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O657.3;R284.1

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