新型吲唑类、四嗪类与吡啶并吡唑类农药的合成及其生物活性研究
发布时间：2018-11-21 10:10
【摘要】：本文通过模仿、改造、替换基团,设计并合成了一系列新型吲唑类、四嗪类以及吡啶并吡唑酰胺类农药,并通过气质联用、核磁氢谱等检测手段对其化学结构进行验证表征,样品经过生物活性测试,筛选出了多个优于现有商业品种的农药新品种。吲唑类植物生长调节剂,具有促进根系生长以及对水分的吸收,还可以加速果实的脱落和成熟。本文主要对吲唑乙氧酸(酯)的结构进行模仿改造,并合成了一系列6个吲唑类化合物,生物活性测试表明,其中化合物Ⅰ、化合物Ⅱ具有较高活性,它们对小麦的发芽和根系生长有良好的促进作用,促进率都超过了相对应的参照化合物。氟螨嗪是目前效果较好、杀螨广谱的农药品种,对多种害螨都具有较好的防治效果;氟螨嗪不仅对螨卵有特效,同时对幼螨也有不错的效果,而且氟螨嗪还对雌成螨有绝育的作用。本文根据氟螨嗪的结构特点,改变四嗪环两侧的活性基团,合成了一系列6个四嗪类化合物,其中化合物Ⅲ、化合物Ⅳ的杀螨效果远远超过对照药氟螨嗪。含吡啶连吡唑的酰胺类杀虫剂氯虫苯甲酰胺,是一种杀虫速度快、杀虫效果好、杀虫广谱的杀虫剂,常被用于蔬菜、水果、水稻、棉花等农作物害虫的防治。氯虫苯甲酰胺的杀虫效果不只作用于成虫,而且对于幼虫也有良好的生物活性,且杀虫效果迅速、具有长持效。本文设计合成制备了13种未见报道的吡啶并吡唑和吡啶并异VA唑芳香酰胺类化合物,并对其进行了杀虫生物活性测试,其中大部分都具有活性,部分化合物活性较高,但均未超过氯虫苯甲酰胺。
[Abstract]:In this paper, a series of new indazole, tetrazines and pyridinopyrazolamide pesticides were designed and synthesized by imitating, modifying and replacing groups, and their chemical structures were characterized by GC-MS and NMR. After bioactivity test, several new pesticide varieties were selected which were superior to the existing commercial varieties. Indazole plant growth regulators can promote root growth and water absorption, but also accelerate fruit shedding and maturation. In this paper, the structure of indazolyl ethoxy acid (ester) was modified, and a series of 6 indazole compounds were synthesized. The bioactivity test showed that compounds I and II had high activity. They had a good promoting effect on wheat germination and root growth, and the promotion rate was higher than the corresponding reference compound. Tetromethazine is one of the most effective and widely acaricidal pesticide varieties, which has good control effect on a variety of harmful mites. Tetromethazine not only has a special effect on the eggs of mites, but also has a good effect on young mites, and also has sterilizing effect on female adult mites. A series of six tetrazines were synthesized according to the structural characteristics of Tetromethazine and the active groups on both sides of the tetrazine ring. The mite killing effect of compounds 鈪，
本文编号：2346664
[Abstract]:In this paper, a series of new indazole, tetrazines and pyridinopyrazolamide pesticides were designed and synthesized by imitating, modifying and replacing groups, and their chemical structures were characterized by GC-MS and NMR. After bioactivity test, several new pesticide varieties were selected which were superior to the existing commercial varieties. Indazole plant growth regulators can promote root growth and water absorption, but also accelerate fruit shedding and maturation. In this paper, the structure of indazolyl ethoxy acid (ester) was modified, and a series of 6 indazole compounds were synthesized. The bioactivity test showed that compounds I and II had high activity. They had a good promoting effect on wheat germination and root growth, and the promotion rate was higher than the corresponding reference compound. Tetromethazine is one of the most effective and widely acaricidal pesticide varieties, which has good control effect on a variety of harmful mites. Tetromethazine not only has a special effect on the eggs of mites, but also has a good effect on young mites, and also has sterilizing effect on female adult mites. A series of six tetrazines were synthesized according to the structural characteristics of Tetromethazine and the active groups on both sides of the tetrazine ring. The mite killing effect of compounds 鈪，
本文编号：2346664
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