喹啉酮类化合物的简便合成
发布时间：2019-01-10 17:25
【摘要】：设计以简单易得合成子β-烯胺酮1为原料,以氰基乙酸2为酰基化试剂,得到烯胺酮的α-C区域选择性氰基乙酰化产物3.进而从化合物3出发,以乙腈为溶剂,哌啶为催化剂,在40℃下,通过分子内环合反应,简洁、高效合成了一类结构新颖的喹啉酮类杂环化合物4a~4t,产率82~95%.该方法具有操作简便、原子经济、原料易得、后处理简单等优点.
[Abstract]:The 伪 -C region-selective cyanoacetylation product 3of enamine ketone was prepared by using simple and easy synthesis of 尾 -enamine ketone 1 as raw material and cyanoacetic acid 2 as acylation reagent. From compound 3, using acetonitrile as solvent and piperidine as catalyst, a class of novel quinolinone heterocyclic compounds 4a1 4t was synthesized by intramolecular cyclization at 40 鈩，
本文编号：2406589
[Abstract]:The 伪 -C region-selective cyanoacetylation product 3of enamine ketone was prepared by using simple and easy synthesis of 尾 -enamine ketone 1 as raw material and cyanoacetic acid 2 as acylation reagent. From compound 3, using acetonitrile as solvent and piperidine as catalyst, a class of novel quinolinone heterocyclic compounds 4a1 4t was synthesized by intramolecular cyclization at 40 鈩，
本文编号：2406589
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