柠檬酸钠稳定的金纳米粒子测定和识别β-受体阻滞剂中的普萘洛尔
发布时间：2019-01-21 09:05
【摘要】：高灵敏的由柠檬酸钠稳定的金纳米粒子通过共振瑞利散射法(RRS)和比色法测定普萘洛尔。利用柠檬酸钠作为还原剂,成功合成了表面带负电的金纳米粒子。在pH 4.6的BR缓冲溶液中,普萘洛尔由于质子化带正电,因此金纳米粒子与普萘洛尔可以通过静电作用结合,从而使金纳米粒子聚集,导致体系的RRS信号增强,并且伴随溶液的颜色由酒红色变成紫色。一种高灵敏的RRS和比色法因此建立起来用于测定普萘洛尔,两种方法对应的线性范围分别为0.2 5.2和0.4 4.4μg·mL-1。但是将该方法用于其他洛尔类药物(比索洛尔、阿替洛尔、美托洛尔和阿罗洛尔)的测定,发现这些洛尔类药物对柠檬酸钠修饰的金纳米粒子探针没有如普萘洛尔般的响应,因此可以用此法识别洛尔类药物混合物中的普萘洛尔。
[Abstract]:A highly sensitive gold nanoparticles stabilized by sodium citrate were used to determine propranolol by resonance Rayleigh scattering (RRS) and colorimetry. Gold nanoparticles with negative charge on the surface were successfully synthesized by using sodium citrate as reducing agent. In the BR buffer solution of pH 4.6, propranolol can bind gold nanoparticles to propranolol by electrostatic interaction because of the positive charge of propranolol band, which leads to the aggregation of gold nanoparticles and the enhancement of RRS signal of the system. And with the color of the solution from wine red to purple. A highly sensitive RRS and colorimetric method was established for the determination of propranolol. The linear ranges of the two methods are 0.2 渭 g mL-1. and 0.4 渭 g mL-1., respectively. However, the method was applied to the determination of other propranolol drugs (Bisoprolol, atenolol, metoprolol and arrolol) and found that these drugs did not respond as propranolol to sodium citrate modified gold nanoparticles probes. Therefore, this method can be used to identify propranolol in prolol drug mixtures.
【作者单位】： 重庆三峡学院;
【分类号】：O657.3;TQ460.72
本文编号：2412504
[Abstract]:A highly sensitive gold nanoparticles stabilized by sodium citrate were used to determine propranolol by resonance Rayleigh scattering (RRS) and colorimetry. Gold nanoparticles with negative charge on the surface were successfully synthesized by using sodium citrate as reducing agent. In the BR buffer solution of pH 4.6, propranolol can bind gold nanoparticles to propranolol by electrostatic interaction because of the positive charge of propranolol band, which leads to the aggregation of gold nanoparticles and the enhancement of RRS signal of the system. And with the color of the solution from wine red to purple. A highly sensitive RRS and colorimetric method was established for the determination of propranolol. The linear ranges of the two methods are 0.2 渭 g mL-1. and 0.4 渭 g mL-1., respectively. However, the method was applied to the determination of other propranolol drugs (Bisoprolol, atenolol, metoprolol and arrolol) and found that these drugs did not respond as propranolol to sodium citrate modified gold nanoparticles probes. Therefore, this method can be used to identify propranolol in prolol drug mixtures.
【作者单位】： 重庆三峡学院;
【分类号】：O657.3;TQ460.72
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